Kinase inhibitors

A compound of the formula:

• 29
• wherein:
• A is O, NH2, NH(C1-C6 alkyl), N(C1-C6 alkyl)2, or —NHC(O)—NHR12;
• R12 is C1-C6 straight or branched chain alkyl, or —(CH2)n—C3-C8 cycloalkyl ring;
• n is an integer of from 1 to 3;
• B, C and D are independently selected from CH or N, with the proviso that C and D are not both N;
• R1 is selected from the group of C1-C6 straight or branched chain alkyl, optionally substituted by —COOH, or;
• a) a phenyl, benzyl or C3-C8 cycloalkyl ring, or —CH2—C3-C8 cycloalkyl ring, with the phenyl, benzyl or cycloalkyl rings being optionally substituted by 1 or 2 COOH or —CH2—COOH groups;
• or
• b) a piperidine or piperazine moiety selected from group of:
• 30
• the rings of the piperidine or piperazine moieties being optionally substituted by 1 or 2 COOH or —CH2—COOH groups;
• or
• c) a tetrahydropyran or morpholine moiety of the formulae:
• 31
• R2 is H, Cl or F;
• R3 is H, Cl or F, with the proviso that at least one of R2 or R3 is F;
• R4 is H, OH, —OCH3, or —OCH2CH3, with the proviso that, if R4 is H, R2 and R3 are not H;
• R5 is —OCH3, or —OCH2CH3;
• R6 is selected from the group of H, —(C1-C5 alkyl)—NH2, —(C1-C5 alkyl)—NH—(C1-C3 alkyl)—R11, —(C1-C5 alkyl)—N—(C1-C3 alkyl-R11)2, —O—(C1-C5 alkyl)—NH2, —O—(C1-C5 alkyl)—NH—(C1-C3 alkyl)—R11, —O—(C1-C5 alkyl)—N—(C1-C3 alkyl—R11)2, —CH(CH2OH)2, —(C1-C3 alkyl)—(CH2OH)2, —(C1-C3 alkyl)—O—(C1-C3 alkyl)—R11, —(C1-C3 alkyl)—O—(C1-C3 alkyl)—NH2, —(C1-C3 alkyl)—O—(C1-C3 alkyl)—NH—(C1-C3 alkyl)—R11, —(C1-C3 alkyl)—O—(C1-C3 alkyl)—N(C1-C3 alkyl—R11)2, phenyl substituted by one or two groups selected from NH2, —N(C1-C3 alkyl), —N(C1-C3 alkyl)2, CN or —(C1-C3 alkyl)-tetrazole, or C1-C6 alkyl,
• 32
• with each of the alkyl chains of any group in this R4 definition being optionally substituted by from 1 to 4 OH groups;
• R7 in each instance is independently selected from H, —NH2, NH(C1-C3 alkyl), N(C1-C3 alkyl)2, or C1-C3 alkyl;
• R8 is H, OH or C1-C3 alkyl;
• 9H, OH, —NH2, NH(C1-C3 alkyl), or N(C1-C3 alkyl)2;
• R10 is H or C1-C3 alkyl;
• R11 is H, CN, OH, NH2, F, or CF3;
• or a pharmaceutically acceptable salt or ester form thereof.