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US 2004/0019201 A1Published application
1,3-Dipolar cycloadditions to polypyrrolic macrocycles
AssigneeThe University of British Columbia
InventorsJill Kirsten MacAlpine, Ethan D. Sternberg, David Dolphin
Life of this patent
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Abstract
Methods of modifying polypyrrolic macrocycles by use of a 1,3-dipolar cycloaddition is described. The methods may be used to produce compounds for further derivatization to produce photosensitizing agents of interest.
Claims20
A method of modifying a polypyrrolic macrocycle, said method comprising
- reacting said macrocycle with a carbonyl ylide capable of forming a cyano containing macrocycle under refluxing conditions to produce a cyano containing compound, and
- reducing a cyano group of said compound with a reducing agent to produce an amine group.
A method of modifying a polypyrrolic macrocycle, said method comprising
- reacting said macrocycle with a carbonyl ylide capable of forming a cyano containing macrocycle under refluxing conditions to produce a cyano containing compound, and
- hydrolyzing a cyano group of said compound to produce an acid or carboxylate moiety.
Dependencies are inferred from the claim text.