New derivatives of lipoic acid, their preparation, their use as medicaments and the pharmaceutical compositions containing them

Product of general formula (I), characterized in that it comprises the products of sub-formulae (I)a and (I)b

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• in which
• R1 and R2 represent independently a hydrogen atom or a linear or branched alkyl radical with 1 to 6 carbon atoms;
• A represents one of the —(CH2)m—NR3CO(CH2)n—, —(CH2)m—CONR3—(CH2)n—, —(CH2)m—NR3—(CH2)n—, —(CH2)m—CONR3—(CH2)p—NR4—(CH2)n—, —(CH2)m—NR3—CO—NR4—(CH2)n— or —(CH2)m— radicals,
• m and n being integers from 0 to 6,
• p being an integer from 2 to 6,
• and R3 and R4 representing independently a hydrogen atom or a linear or branched alkyl radical with 1 to 6 carbon atoms;
• X represents a
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• radical, in which the T group, which is attached to the Y group, represents a —(CH2)i— radical in which i represents an integer comprised between 0 and 6, and R5 represents a hydrogen atom, a linear or branched alkyl radical having 1 to 6 carbon atoms or a —(CH2)m—Q radical in which Q represents a halogen atom or a hydroxy, cyano, amino, alkoxy, alkylamino or dialkylamino radical, or also R5 represents a heterocycle with 5 to 6 members the heterocyclic members of which are chosen from the —O—, —N(R6— and —S— radicals, R6 representing a hydrogen atom or a linear or branched alkyl having 1 to 6 carbon atoms or the bond to the phenyl ring of the X radical;
• or also X represents a —(CH2)q— radical in which q represents an integer comprised between 0 and 6;
• and finally Y represents one of the
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• radicals in which:
• B represents a linear or branched alkyl radical having 1 to 6 carbon atoms, carbocyclic or heterocyclic aryl with 5 or 6 members containing 1 to 4 heteroatoms chosen from O, S, N and in particular the thiophene, furane, pyrrole or thiazole radicals, the aryl radical being optionally substituted by one or more groups chosen from the linear or branched alkyl, alkenyl or alkoxy radicals having 1 to 6 carbon atoms,
• or B represents NR8R9, in which R8 and R9 represent, independently, a hydrogen atom or a linear or branched alkyl radical having 1 to 6 carbon atoms, or one of R8 and R9 represents a nitro radical while the other represents a hydrogen atom or a linear or branched alkyl radical having 1 to 6 carbon atoms, or R8 and R9 together form with the nitrogen atom a non-aromatic heterocycle with five to six members, the elements of the chain being chosen from a group composed of —CH2—, —NH—, —O— or —S—,
• or also B represents an SR10 radical in which R10 represents a hydrogen atom or a linear or branched alkyl radical having 1 to 6 carbon atoms,
• and R7 represents a hydrogen atom or a linear or branched alkyl radical with 1 to 6 carbon atoms;
• or a salt of a product of general formula (I).