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US 2004/0018992 A1Published application
Pharmaceutical compositions for sparingly soluble therapeutic agents
OwnerUlrich Posanskiinventor
Life of this patent
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Abstract
The invention relates to pharmaceutical compositions for sparingly soluble therapeutic agents as well as to a process for the preparation of such compositions. The solubiliser is polyglycerol fatty acid ester or sorbitan fatty acid ester in combination with lipophilic excipients and nonionic surfactants.
Claims10
A pharmaceutical composition for the solubilisation of a therapeutic agent which is sparingly soluble in water, excluding cyclosporins, in a carrier composition comprising:
- a) c. 10-50% by weight, based on the carrier composition, of a co-surfactant which is substantially pure or which is in the form of a mixture, having a hydrophilic-lipophilic balance of less than 10 (HLB value according to Griffin), selected from the group consisting of polyglycerol fatty acid esters and sorbitan fatty acid esters;
- b) c. 5-40% by weight, based on the carrier composition, of a pharmaceutically acceptable oil which is substantially pure or which is in the form of a mixture, comprising a triglyceride as essential lipophilic component;
- and
- c) c. 10-50% by weight, based of the carrier composition, of a nonionic surfactant which is substantially pure or which is in the form of a mixture, having a HLB value of more than 10;
- and further optional pharmaceutically acceptable excipients:
2 more elements
Dependencies are inferred from the claim text.