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US 2004/0018952 A1Published application
Triggered response compositions
OwnerRichard Thomas Gray, Barry Weinsteininventors
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Abstract
This invention provides a triggered response composition in the form of a barrier material and a delivery device that includes one or more polyelectrolytes in contact with an aqueous system that is stable and insoluble in an aqueous system and that exhibits one or more chemical/physical responses in the aqueous system, wherein the chemical/physical response of the composition is triggered upon a change of the chemical/physical properties in the aqueous system.
Claims8
A triggered response composition comprising:
- one or more polyelectrolytes in contact with an aqueous system that is stable and insoluble in an aqueous system at relatively high ionic strength equivalent to 0.5 M sodium chloride or higher or base concentration of between 1.0 M to 2.5 M or higher and that disperses, disintegrates, dissolves, destabilizes, swells, or combinations thereof, wherein the chemical/physical response of the composition is triggered upon one or more ionic strength or base strength changes to the aqueous system;
- wherein the polyelectrolyte is one or more alkali soluble polymers comprising:
- (a) 5-70 weight percent of acidic monomers selected from methacrylic acid, 2-methylpropionic acid or acrylic acid;
- (b) 30-95 weight percent of one or more non-ionic vinyl monomers selected from butyl acrylate, styrene and methyl methacrylate and optionally, (c) 0.01 to 5 weight percent of one or more metal cross-linking agents.
1 more element
A triggered response barrier composition comprising:
- one or more polyelectrolytes in contact with an aqueous system, wherein the polyelectrolyte is one or more alkali soluble polymers comprising:
- (a) 5-70 weight percent of acidic monomers selected from methacrylic acid, 2-methylpropionic acid or acrylic acid;
- (b) 30-95 weight percent of one or more non-ionic vinyl monomers selected from butyl acrylate, styrene and methyl methacrylate and optionally, (c) 0.1 to 5 weight percent of one or more metal cross-linking agents, wherein the barrier composition surrounds one or more active ingredients;
- wherein the barrier composition is stable and insoluble in an aqueous system at relatively high ionic strength or base strength;
- wherein the barrier exhibits one or more chemical/physical responses selected from dispersing, disintegrating, dissolving, destabilizing, swelling, softening, flowing and combinations thereof;
- wherein the chemical/physical response of the composition is triggered upon one or more ionic strength or base strength changes to the aqueous system;
- and wherein the barrier composition is capable of releasing the active ingredients to the aqueous system as a result of the triggered response.
4 more elements
A process for triggering the release of one or more active ingredients to an aqueous system comprising the steps of:
- (a) surrounding one or more active ingredients with an ionic strength or base strength responsive barrier composition, wherein the composition includes one or more one or more alkali soluble polymers comprising:
- (a) 5-70 weight percent of acidic monomers selected from methacrylic acid, 2-methylpropionic acid or acrylic acid;
- (b) 30-95 weight percent of one or more non-ionic vinyl monomers selected from butyl acrylate, styrene and methyl methacrylate and optionally, (c) 0.1 to 5 weight percent of one or more metal cross-linking agents the barrier being substantially impermeable to releasing the active ingredients to the aqueous system and remaining insoluble in the aqueous system;
- and
- (b) altering the ionic strength or the base strength of the aqueous system;
- wherein the barrier composition disperses, disintegrates, dissolves or swells and becomes substantially permeable, thereby triggering the release of the active ingredients into the aqueous system.
3 more elements
Dependencies are inferred from the claim text.