Mutations in the macrophage scavenger receptor 1 gene alter risk of prostate cancer, asthma, and cardiovascular disease
AssigneeWake Forest University Health Sciences
InventorsJianfeng Xu, Deborah Meyers, Sigun Zheng, Patrick C. Walsh, William B. Isaacs, Eugene Bleecker, David Herrington
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Abstract
The present invention discloses methods of screening a subject for increased likelihood or risk of certain diseases or disorders. This method comprises detecting the presence or absence of at least one mutation in the MSR1 gene wherein the presence or absence of such mutation indicates an increased risk for certain diseases, such as cancer asthma and/or cardiovascular diseases.
Claims22
A method of screening a subject for increased risk of prostate cancer, increased risk of asthma, or decreased risk of cardiovascular disease, comprising:
- detecting the presence or absence of an MSRI mutation in said subject;
- and then
- determining that said subject is at increased risk of prostate cancer, increased risk of asthma, or decreased risk of cardiovascular disease due to the presence or absence of said MSRI mutation;
- said MSR1 mutation selected from the group consisting of the H441R mutation, the G369S mutation, the R293X mutation, the P275A mutation, the DF174Y mutation, the V113A mutation, the S41Y mutation, the P36A mutation, and the 154V mutation.
A method of conducting a trial on a plurality of human patients, said method comprising:
- administering a test therapy to said plurality of subjects;
- detecting the presence or absence of at least one MSR1 mutation in said plurality of subjects;
- and then
- determining the influence of the presence or absence of at least one MSR1 mutation on said test therapy, wherein the at least one MSR1 mutation selected from the group consisting of the H441R mutation, the G369S mutation, the R293X mutation, the P275A mutation, the DF174Y mutation, the V113A mutation, the S41Y mutation, the P36A mutation, and the 154V mutation.
An isolated human macrophage scavenger receptor protein having a mutation selected from the group consisting of the H1441 R mutation, the G369S mutation, the R293X mutation, the P275A mutation, the DF174Y mutation, the VI 13A mutation, the S41Y mutation, the P36A mutation, and the 154V mutation.
Dependencies are inferred from the claim text.