Mutated immunogenic peptides derived from R9M, polynucleotides coding for same and therapeutic uses thereof

Selection procedure for therapeutic molecules capable of inducing a protective immune response in vivo against fungal, bacterial, viral or tumor wildtype peptides, characterized in that:

• a) a tumor cell line EL4S3-Rob doubly transfected with nucleotide sequences coding for the HHD molecule and nucleotide sequences coding for the said fungal, bacterial, viral or tumor wildtype peptides is administered to an animal model, the said animal model having a genotype compatible with that of the said tumor cell transfected and having been immunized beforehand with the said molecules that it is desired to select;
• b) the capacity of the said transfected cells to induce a response in vivo against the epitopes of the said fungal, bacterial, viral or tumor peptides is compared with the capacity of the said fungal, bacterial, viral or tumor wildtype peptides to induce a response in vivo against the epitopes of the said wildtype peptides in an animal model subjected to prior immunization with the wildtype peptide sequences of the said therapeutic molecules.