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AssigneeNihon Medi-Physics Co., Ltd.
InventorsAdriano Duatti, Cristina Bolzati, Licia Uccelli, Alessandra Boschi, Fiorenzo Refosco, Francesco Tisato
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A radiopharmaceutical for diagnostic imaging containing as an active ingredient a technetium-99m nitride heterocomplex comprising technetium-99m nitride and two different ligands coordinated therewith, i.e., a bisphosphinoamine compound as a π electron acceptor and a bidentate ligand as a π electron donor and represented by the following formula (I): [99mTc(N)(PNP)(XY)]+ (I)wherein 99mTc(N) is technetium-99m nitride, PNP is a bisphosphinoamine compound and XY is a bidentate ligand, is markedly accumulated in heart and adrenal glands and hence is useful for radiodiagnostic imaging of heart and adrenal glands.
A radiopharmaceutical for diagnostic imaging comprising as an active ingredient a technetium-99m nitride heterocomplex comprising technetium-99m nitride and two different ligands coordinated therewith, i.e., a bisphosphinoamine compound as a π electron acceptor and a bidentate ligand as a π electron donor and represented by the following formula (1):
A kit for preparing a radiopharmaceutical for diagnostic imaging according to 13, wherein the contents of the containers have been freeze-dried.
A kit for preparing a radiopharmaceutical for diagnostic imaging according to 13 or 14, wherein the nitride nitrogen donor is selected from the group consisting of dithiocarbazic acid, dithiocarbazic acid derivatives, hydrazine and hydrazine derivatives.
Dependencies are inferred from the claim text.