Compositions and methods for the treatment of matrix metalloproteinase-related diseases
AssigneeBioInterface Technologies, Inc.
InventorChristopher J. Capelli
Life of this patent
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Abstract
The present invention relates to the use of water-soluble photo-stable silver thiosulfate ion complexes that are antimicrobially active and inhibit the activity of metalloproteinases. The present invention describes incorporation of these complexes into medical devices and/or wound dressings to prevent or treat symptomology related to microbial infections and/or conditions of excessive tissue destruction. In particular, these complexes may be useful in the treatment of rheumatoid arthritis and/or osteoarthritis in the prevention and treatment of articular bone joint degradation and subsequent reductions in joint swelling and pain.
Claims33
A method, comprising:
- a) providing:
- i) a subject, exhibiting at least one symptom associated with a metalloproteinase-associated disease;
- and
- ii) an aqueous solution comprising an effective amount of a water soluble silver-ion complex;
- and
- b) administering said solution to said subject under conditions such that at least one symptom is reduced.
The method of claim 12, wherein said complex is carrier-free.
A method, comprising:
- a) providing:
- i) a subject, exhibiting at least one symptom associated with rheumatoid arthritis;
- and
- ii) an aqueous solution comprising an effective amount of a water soluble silver-ion complex;
- and
- b) administering said solution to said subject under conditions such that at least one symptom is reduced.
A method, comprising:
- a) providing:
- i) a subject, exhibiting at least one symptom associated with osteoarthritis;
- ii) an aqueous solution comprising an effective amount of a water soluble silver-ion complex;
- and
- b) administering said solution to said subject under conditions such that at least one symptom is reduced.
A method, comprising:
- a) providing:
- i) a subject, wherein said subject has a wound;
- ii) an aqueous solution comprising an effective amount of a water soluble silver-ion complex;
- and
- b) administering said solution to said subject under conditions such that the severity of said wound is reduced.
Dependencies are inferred from the claim text.