Method and device for use in tissue approximation and fixation

A method of partitioning a hollow body organ from within, said method comprising:

• positioning a tissue acquisition device into the hollow body organ, said tissue acquisition device having a proximal end and a distal end and a lumen therebetween with a tissue acquiring mechanism at the distal end thereof;
• acquiring a first tissue region and a second tissue region within at least one opening defined in said tissue acquiring mechanism such that said acquired tissue is in juxtaposition with each other;
• translationally moving the first tissue region and the second tissue region relative to each other from a first configuration to a second configuration in which the tissue regions are positioned into apposition with each other;
• advancing a tissue fastening assembly to the juxtaposed tissue, said tissue fastening assembly device having a clamping distal portion;
• and
• actuating the clamping distal portion to engage said tissue folds with a fastening element such that said tissue folds remain affixed to one another.

A method of partitioning a hollow body organ from within, said method comprising:

• positioning a tissue acquisition device into the hollow body organ, said tissue acquisition device having a proximal end and a distal end and a lumen therebetween with a tissue acquiring mechanism at the distal end thereof;
• acquiring a first tissue region within at least one opening defined in said tissue acquiring mechanism;
• advancing a tissue fastening assembly to the first tissue region, said tissue fastening assembly device having a clamping distal portion;
• and
• actuating the clamping distal portion to engage said first tissue region with a fastening element such that said tissue folds remain affixed to one another.

A tissue acquisition device, comprising:

• an elongate main body having a proximal end, a distal end, and a length therebetween;
• a first jaw member and a second jaw member each pivotally connected to the distal end of the main body,
• wherein the first and the second jaw members are adapted to move from a first configuration to a second expanded configuration in which the jaw members are translationally positioned into apposition with each other, and
• wherein the first and the second jaw members each define an opening for acquiring tissue therewithin, each opening being in fluid communication with at least one lumen defined in the main body.

An implantable clamp for affixing a region of tissue within a hollow body organ, comprising:

• a penetrating clamp portion having a first tissue engagement surface which is patterned or textured;
• and
• a receiving clamp portion having a second tissue engagement surface which is patterned or textured and is in apposition to the first tissue engagement surface;
• wherein the penetrating clamp portion has at least one post for piercing through the region of tissue and engaging with the receiving clamp portion.