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US 2004/0006276 A1Published application
Autofluorescence detection and imaging of bladder cancer realized through a cystoscope
AssigneeThe Regents of the University of California
InventorsStavros G. Demos, Ralph W. deVere White
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Abstract
Near infrared imaging using elastic light scattering and tissue autofluorescence and utilizing interior examination techniques and equipment are explored for medical applications. The approach involves imaging using cross-polarized elastic light scattering and/or tissue autofluorescence in the Near Infra-Red (NIR) coupled with image processing and inter-image operations to differentiate human tissue components.
Claims38
A diagnostic apparatus, comprising:
- at least one electromagnetic radiation source directed to illuminate one or more tissue components,
- an interior examination device adapted to transmit the radiation source for illumination of the tissue components and further adapted to relay a near-infrared scattered and/or an autofluorescence emission radiation of the illuminated tissue components,
- a detector adapted to capture from the tissue components, a near-infrared scattered and/or a near infrared autofluorescence emission radiation that is relayed by the interior examination device;
- and
- means to characterize the captured near-infrared scattered and/or near infrared autofluorescence emission radiation from the tissue components.
2 more elements
A diagnostic apparatus, comprising:
- at least two substantially narrow-band electromagnetic radiation wavelength sources directed to illuminate one or more tissue components,
- an interior examination device adapted to transmit the wavelength sources for illumination of the tissue components and further adapted to relay a near-infrared scattered radiation of the illuminated tissue components,
- a detector adapted to simultaneously capture one or more images produced by the near-infrared scattered radiation from the tissue components;
- and
- means to characterize the captured near-infrared scattered radiation from the tissue components.
2 more elements
A diagnostic apparatus, comprising:
- one or more laser sources directed to illuminate one or more tissue components,
- a cystoscope adapted to transmit the laser sources for illumination of the tissue components and further adapted to relay a near-infrared scattered electromagnetic and/or a near infrared autofluorescence emission radiation of the illuminated tissue components,
- an on-chip charge amplification CCD adapted to capture images produced by a near-infrared scattered electromagnetic and/or a near infrared autofluorescence emission radiation from the tissue components;
- and
- a computer configured with an image processing software to characterize the captured near-infrared scattered and/or near-infrared autofluorescence emission radiation from the tissue components.
2 more elements
A diagnostic apparatus, comprising:
- at least two laser sources directed to illuminate one or more tissue components,
- a cystoscope adapted to transmit the laser sources for illumination of the tissue components and further adapted to relay a scattered near-infrared radiation produced by the illuminated tissue components,
- a two-dimensional CCD, adapted to simultaneously capture images produced by the scattered near-infrared radiation from the tissue components;
- and
- a computer configured with an image processing software to characterize the captured near-infrared scattered radiation from the tissue components.
2 more elements
A diagnostic method, comprising:
- interrogating one or more tissue components with an interior examination device, wherein the device is capable of directing one or more substantially narrow band electromagnetic radiation sources to provide illumination of one or more tissue components and further capable of relaying a near infrared scattered and/or a near infrared autofluorescence emission radiation from the illuminated tissue components,
- detecting the near infrared scattered and/or the near infrared autofluorescence emission radiation from the tissue components;
- and
- characterizing the detected near-infrared scattered and autofluorescence emission radiation from the tissue components.
1 more element
Dependencies are inferred from the claim text.