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US 2004/0006254 A1Published application
Pharmaceutically enhanced low-energy radiosurgery
AssigneeSirius Medicine, LLC
InventorsMichael Weil, Kevin N. Morris
Life of this patent
Estimating the term…
Abstract
Contrast agents developed specifically for x-ray diagnostics provide dose-enhanced radiotherapy and radiosurgery. The presence of heavy elements, for example, gold or iron, from these contrast agents, even small quantities, leads to a major dose increase in target tissue when combined with in vivo calibration of the amount of contrast agent. The technique can also be used in combination with other techniques, such as focused x-rays, to achieve further enhancement of therapeutic ratio. The technique is enhanced by employing oil-based contrast agents, which will remain in the target much longer than conventional agents. Through optimization of the equipment it is possible to achieve very large ratios of dose in target to dose in healthy tissue.
Claims40
A method for treating tumors by radiosurgery with focused x-rays comprising the steps of:
- (a) delivering an amount of a contrast agent into a tumor;
- (b) calibrating the amount of said contrast agent within said tumor to determine x-ray dose enhancement;
- (c) repeating steps a and b until a desired amount of said contrast agent is delivered into said tumor to provide a desired amount of x-ray dose enhancement;
- (d) irradiating said tumor containing said desired amount of said contrast agent with said focused x-rays,
- wherein said focused x-rays are achieved by arcing.
2 more elements
A method for treating tumors by radiosurgery with focused x-rays comprising the steps of:
- (a) delivering an amount of a contrast agent into a tumor;
- (b) calibrating the amount of said contrast agent within said tumor to determine x-ray dose enhancement;
- (c) repeating steps a and b until a desired amount of said contrast agent is delivered into said tumor to provide a desired amount of x-ray dose enhancement;
- (d) irradiating said tumor containing said desired amount of said contrast agent with said focused x-rays;
- wherein said focused x-rays are achieved by collimation.
2 more elements
A method for treating tumors by radiosurgery with focused x-rays comprising the steps of:
- (a) delivering an amount of a contrast agent into a tumor;
- (b) calibrating the amount of said contrast agent within said tumor to determine x-ray dose enhancement;
- (c) repeating steps a and b until a desired amount of said contrast agent is delivered into said tumor to provide a desired amount of x-ray dose enhancement;
- (d) irradiating said tumor containing said desired amount of said contrast agent with said focused x-rays;
- wherein said focused x-rays are achieved by multiple static beams.
2 more elements
A method for treating tumors by radiosurgery with x-rays comprising the steps of:
- (a) delivering an amount of a contrast agent into a tumor;
- (b) calibrating the amount of said contrast agent within said tumor to determine x-ray dose enhancement;
- (c) repeating steps a and b until a desired amount of said contrast agent is delivered into said tumor to provide a desired amount of x-ray dose enhancement;
- (d) irradiating said tumor containing said desired amount of said contrast agent with x-rays,
- said method resulting in an x-ray dose ehancement in said tumor of about 2:1 to about 10:1;
- wherein said contrast agent is selected from the group consisting of manganese, iron, NC100150, Clariscan, Echogen, code 7228, Combidex, Imagent, BR-1, Gastromiro, LumenHance, MultiHance, SonoRx, Uromiro, Tomojet, Definity, MS-325, Optimark, Sinerem, Telebrix, Optiject, Dotarem, Endorem, Lipiodol U. F., Bleu Patenté V. Prepacol, Gastrobul, Angiomark, Liebel-Flarsheim contrast injectors, Optison, Albunex, MB-840, Oralex, Abdoscan, Imagopaque, Sonazoid, Gadolite, Biliscopin, Gadovist, Isovist, and Medrad.
3 more elements
A method for treating tumors by radiosurgery with x-rays, said method comprising the steps of:
- (a) injecting an amount of a contrast agent into a tumor;
- (b) calibrating the amount of said contrast agent within said tumor to determine x-ray dose enhancement with the equation de=1+1.3p, where de means dose enhancement and p is the percentage of said contrast agent by weight in said tumor;
- (c) repeating steps a and b until a desired amount of said contrast agent is injected into said tumor to provide a desired amount of x-ray dose enhancement;
- (d) irradiating said tumor containing said desired amount of said contrast agent with x-rays having an energy of between about 40 keV and about 80 keV,
- wherein said desired amount of said contrast agent results in an x-ray dose enhancement in said tumor of about 2:1 to about 10:1;
- and
- wherein said contrast agent is selected from the group consisting of manganese, iron, NC100150, Clariscan, Echogen, code 7228, Combidex, Imagent, BR-1, Gastromiro, LumenHance, MultiHance, SonoRx, Uromiro, Tomojet, Definity, MS-325, Optimark, Sinerem, Telebrix, Optiject, Dotarem, Endorem, Lipiodol U. F., Bleu Patenté V. Prepacol, Gastrobul, Angiomark, Liebel-Flarsheim contrast injectors, Optison, Albunex, MB-840, Oralex, Abdoscan, Imagopaque, Sonazoid, Gadolite, Biliscopin, Gadovist, Isovist, and Medrad.
4 more elements
A method for treating tumors by radiosurgery with x-rays, said method comprising the steps of:
- (a) injecting an amount of a contrast agent into a tumor;
- (b) calibrating the amount of said contrast agent within said tumor to determine x-ray dose enhancement by the steps of:
- (i) scanning said tumor injected with said contrast agent with a computed tomography scanner;
- (ii) determining a Hounsfield number H in said tumor with said computed tomography scanner;
- (iii) using said Hounsfield number H to calculate the dose enhancement with the equation de=1+0.0025H;
- (c) repeating steps a and b until a desired amount of said contrast agent is injected into said tumor to provide a desired amount of x-ray dose enhancement;
- (d) irradiating said tumor containing said desired amount of said contrast agent with x-rays having an energy of between about 40 keV and about 80 keV,
- wherein said desired amount of said contrast agent results in an x-ray dose enhancement in said tumor of about 2:1 to about 10:1;
- and
- wherein said contrast agent is selected from the group consisting of manganese, iron, NC100150, Clariscan, Echogen, code 7228, Combidex, Imagent, BR-1, Gastromiro, LumenHance, MultiHance, SonoRx, Uromiro, Tomojet, Definity, MS-325, Optimark, Sinerem, Telebrix, Optiject, Dotarem, Endorem, Lipiodol U. F., Bleu Patenté V. Prepacol, Gastrobul, Angiomark, Liebel-Flarsheim contrast injectors, Optison, Albunex, MB-840, Oralex, Abdoscan, Imagopaque, Sonazoid, Gadolite, Biliscopin, Gadovist, Isovist, and Medrad.
7 more elements
A method for treating tumors by radiosurgery with x-rays, said method comprising the steps of:
- (a) injecting an amount of a contrast agent into a surface portion of a tumor;
- (b) calibrating the amount of said contrast agent within said surface portion of said tumor to determine x-ray dose enhancement with the equation de=1+1.3p, where de means dose enhancement and p is the percentage of said contrast agent by weight in said surface portion of said tumor;
- (c) repeating steps a and b until a desired amount of said contrast agent is injected into said surface portion of said tumor to provide a desired amount of x-ray dose enhancement;
- (d) irradiating said tumor containing said desired amount of said contrast agent with x-rays having an energy of between about 40 keV and about 80 keV,
- wherein said desired amount of said contrast agent results in an x-ray dose enhancement in said surface portion of said tumor of about 2:1 to about 10:1;
- and
- wherein said contrast agent is selected from the group consisting of manganese, iron, NC100150, Clariscan, Echogen, code 7228, Combidex, Imagent, BR-1, Gastromiro, LumenHance, MultiHance, SonoRx, Uromiro, Tomojet, Definity, MS-325, Optimark, Sinerem, Telebrix, Optiject, Dotarem, Endorem, Lipiodol U. F., Bleu Patenté V. Prepacol, Gastrobul, Angiomark, Liebel-Flarsheim contrast injectors, Optison, Albunex, MB-840, Oralex, Abdoscan, Imagopaque, Sonazoid, Gadolite, Biliscopin, Gadovist, Isovist, and Medrad.
4 more elements
A method for treating tumors by radiosurgery with x-rays, said method comprising the steps of:
- (a) injecting an amount of a contrast agent into a surface portion of a tumor;
- (b) calibrating the amount of said contrast agent within said surface portion of said tumor to determine x-ray dose enhancement by the steps of:
- (i) scanning said surface portion of said tumor injected with said contrast agent with a computed tomography scanner;
- (ii) determining a Hounsfield number H in said surface portion of said tumor with said computed tomography scanner;
- (iii) using said Hounsfield number H to calculate the dose enhancement with the equation de=1+0.0025H;
- (c) repeating steps a and b until a desired amount of said contrast agent is injected into said surface portion of said tumor to provide a desired amount of x-ray dose enhancement;
- (d) irradiating said tumor containing said desired amount of said contrast agent with x-rays having an energy of between about 40 keV and about 80 keV,
- wherein said desired amount of said contrast agent results in an x-ray dose enhancement in said surface portion of said tumor of about 2:1 to about 10:1;
- and
- wherein said contrast agent is selected from the group consisting of manganese, iron, NC100150, Clariscan, Echogen, code 7228, Combidex, Imagent, BR-1, Gastromiro, LumenHance, MultiHance, SonoRx, Uromiro, Tomojet, Definity, MS-325, Optimark, Sinerem, Telebrix, Optiject, Dotarem, Endorem, Lipiodol U. F., Bleu Patenté V. Prepacol, Gastrobul, Angiomark, Liebel-Flarsheim contrast injectors, Optison, Albunex, MB-840, Oralex, Abdoscan, Imagopaque, Sonazoid, Gadolite, Biliscopin, Gadovist, Isovist, and Medrad.
7 more elements
A method for treating tumors by radiosurgery with x-rays, said method comprising the steps of:
- (a) injecting an amount of a contrast agent into a tumor, wherein said step of injecting said contrast agent is directed by ultrasonography;
- (b) calibrating the amount of said contrast agent within said tumor to determine x-ray dose enhancement with the equation de=1+1.3p, where de means dose enhancement and p is the percentage of said contrast agent by weight in said tumor;
- (c) repeating steps a and b until a desired amount of said contrast agent is injected into said tumor to provide a desired amount of x-ray dose enhancement;
- (d) irradiating said tumor containing said desired amount of said contrast agent with x-rays having an energy of between about 40 keV and about 80 keV,
- wherein said desired amount of said contrast agent results in an x-ray dose enhancement in said tumor of about 2:1 to about 10:1;
- and
- wherein said contrast agent is selected from the group consisting of manganese, iron, NC100150, Clariscan, Echogen, code 7228, Combidex, Imagent, BR-1, Gastromiro, LumenHance, MultiHance, SonoRx, Uromiro, Tomojet, Definity, MS-325, Optimark, Sinerem, Telebrix, Optiject, Dotarem, Endorem, Lipiodol U. F., Bleu Patenté V. Prepacol, Gastrobul, Angiomark, Liebel-Flarsheim contrast injectors, Optison, Albunex, MB-840, Oralex, Abdoscan, Imagopaque, Sonazoid, Gadolite, Biliscopin, Gadovist, Isovist, and Medrad.
4 more elements
A method for treating tumors by radiosurgery with focused x-rays, said method comprising the steps of:
- (a) injecting an amount of a contrast agent into a tumor, wherein said step of injecting said contrast agent is directed by ultrasonography;
- (b) calibrating the amount of said contrast agent within said tumor to determine x-ray dose enhancement by the steps of:
- (i) scanning said tumor injected with said contrast agent with a computed tomography scanner;
- (ii) determining a Hounsfield number H in said tumor with said computed tomography scanner;
- (iii) using said Hounsfield number H to calculate the dose enhancement with the equation de=1+0.0025H;
- (c) repeating steps a and b until a desired amount of said contrast agent is injected into said tumor to provide a desired amount of x-ray dose enhancement;
- (d) irradiating said tumor containing said desired amount of said contrast agent with x-rays having an energy of between about 40 keV and about 80 keV,
- wherein said desired amount of said contrast agent results in an x-ray dose enhancement in said tumor of about 2:1 to about 10:1;
- and
- wherein said contrast agent is selected from the group consisting of manganese, iron, NC100150, Clariscan, Echogen, code 7228, Combidex, Imagent, BR-1, Gastromiro, LumenHance, MultiHance, SonoRx, Uromiro, Tomojet, Definity, MS-325, Optimark, Sinerem, Telebrix, Optiject, Dotarem, Endorem, Lipiodol U. F., Bleu Patenté V. Prepacol, Gastrobul, Angiomark, Liebel-Flarsheim contrast injectors, Optison, Albunex, MB-840, Oralex, Abdoscan, Imagopaque, Sonazoid, Gadolite, Biliscopin, Gadovist, Isovist, and Medrad.
7 more elements
A method for treating tumors by immunotherapy with x-rays comprising the steps of:
- (a) delivering an amount of a contrast agent into a tumor;
- (b) calibrating the amount of said contrast agent within said tumor to determine x-ray dose enhancement;
- (c) repeating steps a and b until a desired amount of said contrast agent is delivered into said tumor to provide a desired amount of x-ray dose enhancement;
- (d) irradiating said tumor containing said desired amount of said contrast agent with said x-rays,
- wherein said x-rays produce necrotic cellular debris within said tumor, said necrotice cellular debris eliciting an immune response.
2 more elements
A method for treating tumors by anti-angiogenesis therapy with x-rays comprising the steps of:
- (a) delivering an amount of a contrast agent into a tumor;
- (b) calibrating the amount of said contrast agent within said tumor to determine x-ray dose enhancement;
- (c) repeating steps a and b until a desired amount of said contrast agent is delivered into said tumor to provide a desired amount of x-ray dose enhancement;
- (d) irradiating said tumor containing said desired amount of said contrast agent with said x-rays,
- wherein said x-rays enhance the activity of anti-angiogenesis within said tumor.
2 more elements
A method for treating tumors by chemotherapy with x-rays comprising the steps of:
- (a) delivering an amount of a contrast agent into a tumor;
- (b) calibrating the amount of said contrast agent within said tumor to determine x-ray dose enhancement;
- (c) repeating steps a and b until a desired amount of said contrast agent is delivered into said tumor to provide a desired amount of x-ray dose enhancement;
- (d) irradiating said tumor containing said desired amount of said contrast agent with said x-rays,
- wherein said x-rays increase the therapeutic window of said chemotherapy.
2 more elements
Dependencies are inferred from the claim text.