Process for the preparation of 3, 3-dimethylbutanal

A process for the preparation of 3,3-dimethylbutanal comprising contacting 3,3-dimethylbutanol with a catalyst for the dehydrogenation of an alcohol to a corresponding aldehyde at a turnover ratio of at least 5 moles 3,3-dimethylbutanal per mole catalyst active phase prior to any interruption of the reaction for regeneration of the catalyst.

A process for the preparation of 3,3-dimethylbutanol comprising:

• heating a hydrolysis feed mixture comprising a 3,3-dimethylbutyl ester and a mineral acid in the presence of water, thereby hydrolyzing the ester and producing a hydrolysis reaction mixture comprising 3,3-dimethylbutanol;
• and
• distilling 3,3-dimethylbutanol formed in the hydrolysis from the hydrolysis reaction mixture

A process for the preparation of 3,3-dimethylbutanal comprising:

• contacting a gas phase comprising 3,3-dimethylbutanol and an inert gas with a dehydrogenation catalyst to produce a dehydrogenation reaction product gas containing 3,3-dimethylbutanal at a turnover ratio of at least about 5 moles 3,3-dimethylbutanol per mole catalyst active phase prior to any interruption of the reaction for regeneration of the catalyst;
• and
• recovering 3,3-dimethylbutanal from the dehydrogenation reaction product.

A process as set forth in claim 113 wherein the turnover ratio is at least about 10 moles 3,3-dimethylbutanal per mole catalyst active phase prior to any regeneration of the catalyst.

A process for the preparation of 3,3-dimethylbutanal comprising:

• contacting 3,3-dimethylbutanoic acid or an ester thereof with a reducing agent, thereby producing 3,3-dimethylbutanol;
• and
• converting 3,3-dimethylbutanol to 3,3-dimethylbutanal.

A process for the preparation of 3,3-dimethylbutanal comprising:

• hydrolyzing a substrate selected from the group consisting of 1-chloro-3,3-dimethylbutane, 1-bromo-3,3-dimethylbutane and 1-iodo-3,3-dimethylbutane to produce 3,3-dimethylbutanol;
• and
• converting 3,3-dimethylbutanol to 3,3-dimethylbutanal.

A process for the preparation of 3,3-dimethylbutanal comprising:

• preparing 3,3-dimethylbutanol, the preparation of 3,3-dimethylbutanol comprising hydrolysis of 1-halo-3,3-dimethylbutane or 1-acyloxy-3,3-dimethylbutane in the presence of a base;
• and
• converting 3,3-dimethylbutanol to 3,3-dimethylbutanal.

A process for the preparation of 3,3-dimethylbutanal comprising:

• reducing 1,2-epoxy-3,3-dimethylbutane oxide to 3,3-dimethylbutanol;
• and
• converting 3,3-dimethylbutanol to 3,3-dimethylbutanal.

A process for the preparation of 3,3-dimethylbutanal comprising:

• reacting a t-butyl organometallic compound with ethylene oxide to form 3,3-dimethylbutanol;
• and
• converting 3,3-dimethylbutanol to 3,3-dimethylbutanal.

A process for the preparation of 3,3-dimethylbutanal comprising contacting 3,3-dimethylbutanol with a catalyst for the dehydrogenation of an alcohol to a corresponding aldehyde, said catalyst being substantially non-toxic to humans.