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US 2004/0006240 A1Published application
Process to prepare 11beta,17alpha ,21-trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione 21-acetate
OwnerBruce Allen Pearlmaninventor
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Abstract
The present invention is a novel process for the transformation of 11β,17α dihydroxy-6α-methylpregna-1,4-diene-3,20-dione 17-acetate (III) 1 to 11β,17α,21-trihydroxy-6α-methylpregna-1,4-diene-3,20-dione 21-acetate (VI) 2
Claims13
A process for the preparation of 11β,17α,21-trihydroxy-6α-methylpregna-1,4-diene-3,20-dione 21-acetate (VI) which comprises:
- (1) hydrolyzing the 11β,17α-dihydroxy-6α-methylpregna-1,4-diene-3,20-dione 17-acetate (III) to produce 11β,17α-dihydroxy-6α-methylpregna-1,4-diene-3,20-dione (IV);
- (2) contacting 11β,17α-dihydroxy-6α-methylpregna-1,4-diene-3,20-dione (IV) with iodine, a catalyst, a mild base and a metal bromide salt to produce 1β,17α-dihydroxy-21-diiodo-6α-methylpregna-1,4-diene-3,20-dione (V) and
- (3) contacting 1β,17α-dihydroxy-21-diiodo-6α-methylpregna-1,4-diene-3,20-dione (V) with a salt of acetic acid.
A diiodo steroid of the formula:
- 7
Dependencies are inferred from the claim text.