Diaminopropionic acid derivatives

A compound of formula

• 530
• wherein A3 is hydrogen, hydroxy, amino, or halogen and B3 is amino, carboxy, hydrogen, hydroxy, cyano, trifluoromethyl, halogen, lower alkyl, or lower alkoxy;
• R23 is a group of the formula
• 531
• where R33 is hydrogen, carboxy, or lower alkyl;
• U3, V3, and W3 are independently hydrogen, halogen, or lower alkyl provided U3 and V3 are not both hydrogen;
• R4 is hydrogen, lower alkyl, or aryl-lower-alkyl which can be unsubstituted or substituted with at least one of halogen, cyano, amino, substituted amino, aminosulfonyl, nitro, hydroxy, aryl, aryloxy, unsubstituted lower alkyl, halogen-substituted lower alkyl, lower alkoxy-substituted lower alkyl, lower alkoxy, carboxy, lower alkoxycarbonyl, or acetoxy
• and pharmaceutically acceptable salts and esters thereof.

A compound of formula:

• 532
• wherein R1 is a group of the formula
• 533
• where A is hydrogen, hydroxy, amino, or halogen and B is amino, carboxy, hydrogen, hydroxy, cyano, trifluoromethyl, halogen, lower alkyl, or lower alkoxy;
• R2 is a group of the formula
• 534
• where R3 is hydrogen, carboxy, or lower alkyl;
• n is 0 or 1;
• U, V, and W are independently hydrogen, halogen, or lower alkyl provided U and V are not both hydrogen;
• X is carbonyl, phenyl-substituted loweralkylene, or sulfonyl;
• Y is lower alkylene which may be substituted by one or more of amino, substituted amino, loweralkyl, or cyclo lower alkyl, or Y is lower alkenylene or lower alkylenethio;
• k is 0 or 1;
• when k is 1, Z is:
• hydrogen, lower alkylthio, —COOH, —CONH2, or amino, or when k is 0 or 1, Z is:
• 1-adamantyl, diphenylmethyl, 3-[[(5-chloropyridin-2-yl)amino]carbonyl]pyrazin-2-yl, hydroxy, phenylmethoxy, 2-chloro-4-[[[(3-hydroxyphenyl)methyl]amino]-carbonyl]phenyl, [(2,6-dichlorophenyl)methoxy]phenyl, or Z is one of the following:
• cycloalkyl or aryl containing 0 to 3 heteroatoms which may be the same or different, or a fused ring system containing two or three rings which rings are independently cycloalkyl or aryl containing 0 to 3 heteroatoms which may be the same or different, any of which rings may be unsubstituted, or substituted with at least one of:
• halogen, cyano, amino, substituted amino, aminosulfonyl, nitro, oxo, hydroxy, aryl, aryloxy, unsubstituted lower alkyl, halogen-substituted lower alkyl, lower alkoxy-substituted lower alkyl, lower alkoxy, lower alkanesulfonyl, lower alkylthio, acetyl, aminocarbonyl, hydrazino, carboxy, lower alkoxycarbonyl, acetoxy, or amino loweralkyl;
• R6 is lower alkyl or —CH2CH 2—R7 where R7 is —N(CH3)2,
• 535
• where R8 is hydrogen or methyl and R9 is lower alkyl or lower cycloalkyl;
• and pharmaceutically acceptable salts and esters thereof.