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US 2004/0006233 A1Published application
Synthetic multimerizing agents
AssigneeARIAD Pharmaceuticals, Inc.
InventorsDennis A. Holt, Terence P. Keenan, Tao Guo, Edgardo Laborde, Wu Yang
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Abstract
New compounds are disclosed for multimerizing immunophilins and proteins containing immunophilin or immunophilin-related domains. The compounds are of the formula M-L-Q where M is a synthetic ligand for an FKBP protein
Claims42
A compound of the formula:
- 237
- B1 and B2 are the same or different and are each independently H or a substituted or unsubstituted aliphatic, heteroaliphatic, aryl or heteroaryl moiety;
- X is O, NH or CH2;
- R2 is a substituted or unsubstituted aliphatic, heteroaliphatic, aryl or heteroaryl moiety;
- R4 is H, a substituted or unsubstituted, branched, unbranched, cyclic, saturated or unsaturated, aliphatic or heteroaliphatic group or a substituted or unsubstituted aryl or heteroaryl group;
- R5 is a substituted or unsubstituted, aliphatic moiety of 1 to 8 carbon atoms which may be branched, unbranched or cyclic;
- R6 is a substituted or unsubstituted aliphatic, heteroaliphatic, heterocylic, aryl or heteroaryl moiety;
- and
- R7 is H or —(CH2)mCH═CH2, —(CH2)mCOOH, —(CH2)mCHO, —(CH2)mOH, —(CH2)mSH, —(CH2)mNH2, or —(CH2)mNH(alkyl), where m is 0, 1, 2, 3 or 4 and n is 0 or 1.
6 more elements
Dependencies are inferred from the claim text.