Antibody and antibody fragments for inhibiting the growth of tumors
OwnerNeil I. Goldstein, Nicholas A. Giorgio +2inventors
InventorsNeil I. Goldstein, Nicholas A. Giorgio, Steven Tarran Jones, Jose William Saldanha
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Abstract
Chimerized and humanized versions of anti EGF receptor antibody 225 and fragments thereof for treatment of tumors.
Claims91
A polypeptide lacking the constant region and the variable light chain of an antibody, the polypeptide comprising the amino acid sequence NYGVH, GVIWSGGNTDYNTPFTSR, or VIWSGGNTDYNTPFTS.
A polypeptide consisting of the amino acid sequence NYGVH or GVIWSGGNTDYNTPFTSR.
A polypeptide consisting of the amino acid sequence NYGVH or VIWSGGNTDYNTPFTS.
DNA encoding a polypeptide lacking the constant region and the variable light chain of an antibody, the polypeptide comprising the amino acid sequence NYGVH, GVIWSGGNTDYNTPFTSR or VIWSGGNTDYNTPFTS.
A molecule having the constant region of a human antibody and the hypervariable region of monoclonal antibody 225 conjugated to an effector molecule.
A molecule comprising:
- a constant region of a human antibody;
- a variable region other than the CDRs of a human antibody, the variable region comprising a kappa light chain and a heavy chain, and the CDRs of monoclonal antibody 225.
A method for significantly inhibiting the growth of tumor cells in a human comprising administering to the human an effective amount of a molecule having the constant region of a human antibody and the variable region of monoclonal antibody 225.
A method for significantly inhibiting the growth of tumor cells in a human comprising administering to the human an effective amount of a molecule having a constant region of a human antibody;
- a variable region other than the CDRs of a human antibody, the variable region comprising a kappa light chain and heavy chain, and the CDRs of monoclonal antibody 225.
A nucleic acid molecule that encodes a molecule comprising:
- a constant region of a human antibody;
- a variable region other than the CDRs of a human antibody, the variable region comprising a kappa light chain and a heavy chain, and the CDRs of monoclonal antibody 225.
A vector comprising the nucleic acid molecule claim of 84.
Dependencies are inferred from the claim text.