Aminoalcohol derivatives
AssigneeFujisawa Pharmaceutical Co., Ltd.
InventorsKouji Hattori, Yasuyo Tomishima, Masashi Imanishi
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Abstract
The present invention relates to a compound formula [I]: 1 wherein 2 Y is bond, —O—(CH2)n— (in which n is 1, 2, 3 or 4), etc., Z is cyano, tetrazolyl, etc., R1 is hydrogen, lower alkyl, etc., R2 is hydrogen or an amino protective group, R3 is hydrogen or lower alkyl, R4 is hydrogen or lower alkyl, R5 and R8 are each independently hydrogen, halogen, hydroxy, lower alkyl, etc., R6 is hydrogen, lower alkyl, etc., R9 is hydrogen or lower alkyl, and i is 1 or 2, or a salt thereof. The compound [I] of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of pollakiurea or urinary incontinence.
Claims11
A compound of the formula [I]:
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- X is bond,
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- (in which R7 is hydrogen or lower alkyl),
- Y is bond, —O(CH2)n— (in which n is 1, 2, 3 or 4), (CH2)m— (in which m is 1, 2, 3 or 4),
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- Z is cyano, tetrazolyl, (benzylsulfonyl)carbamoyl, benzoylsulfamoyl, formyl, carboxy or protected carboxy,
- R1 is hydrogen, lower alkyl or halogen,
- R2 is hydrogen or an amino protective group,
- R3 is hydrogen or lower alkyl,
- R4 is hydrogen or lower alkyl,
- R5 and R8 are each independently hydrogen, halogen, hydroxy, lower alkyl, lower alkenyl, lower alkoxy, hydroxy(lower)alkoxy, mono(or di or tri)halo(lower)alkoxy, lower alkoxy(lower)alkoxy, lower alkenyloxy, cyclo(lower)alkyloxy, cyclo(lower)alkyl(lower)alkoxy, benzyloxy, phenoxy, lower alkylthio, cyclo(lower)alkylthio, lower alkylsulfonyl, cyclo(lower)alkylsulfonyl, amino, mono(or di)(lower)alkylamino, mono(or di or tri)halo(lower)alkyl, cyano, piperidinyl or phenyl,
- R6 is hydrogen, lower alkyl or halogen,
- R9 is hydrogen or lower alkyl, and
- i is 1 or 2,
- provided that
- (1) when X is bond,
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- then R5 is not hydrogen, or
- (2) when i is 1,
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- or a salt thereof.
Dependencies are inferred from the claim text.