Activation of the cystic fibrosis transmembrane conductance regulator chloride channel
OwnerDavid Noel Sheppard, Zhiwei Caiinventors
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Abstract
Fluorescein and derivatives have use in the treatment of a disease of condition of a living animal body, including human, which disease is responsive to the activation of the cystic fibrosis transmembrane conductance regulator chloride channels, for instance cystic fibrosis, disseminated brocheiectasis, pulmonary infections, chronic pancreatitis, male infertility and long QT syndrome.
Claims19
The use of a compound of the formula I
- 3
- wherein R1, R2 and R3 may each be the same or a different group selected from H, 1 to 6C alkyl and halo and R4 is a group selected from H and 1 to 6C alkyl, and pharmaceutically-acceptable salts thereof, in the manufacture of a medicament for the treatment of a disease or medical condition of a living animal body, including a human, which disease or condition is responsive to the activation of the cystic fibrosis transmembrane conductance regulator chloride channels.
A method of treating a disease or medical condition of a living animal body, including a human, which disease or condition is responsive to the activation of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channels which method comprises administering to the living animal body a CFTR chloride channel activating amount of a compound of the formula I
- 4
- wherein each of R1, R2 and R3, which may be the same or different, is selected from H, 1 to 6C alkyl and halo and R4 is a group selected from H and 1 to 6C alkyl, and pharmaceutical-acceptable salts thereof.
Dependencies are inferred from the claim text.