2-Oxothiazolidine 4-carboxylic acid compounds for promoting desquamation of the skin
AssigneeSociete L'Oreal S.A.
InventorsJean-Baptiste Galey, Dominique Bernard, Lucie Simonetti
Life of this patent
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Abstract
2-oxothiazolidine-4-carboxylic acid compounds having the structural formula (I): 1 are suited for promoting desquamation of the skin and/or stimulating epidermal renewal and/or combating aging of the skin.
Claims19
A regime or regimen for promoting desquamation of the skin and/or stimulating epidermal renewal and/or combating aging of the skin, comprising administering to an individual in need of such treatment, a thus effective amount of at least one 2-oxothiazolidine-4-carboxylic acid compound having the structural formula (I):
- 7
- in which X is —OH or —NHR2;
- and R1 and R2, which may be identical or different, are each a hydrogen atom, a linear or branched C1-C8 alkyl radical, optionally substituted with at least one radical —OR and/or one radical —COOR and/or one radical —NHR and/or one radical —SR and/or one radical —R in which R is a hydrogen atom or a linear or branched C1-C4 alkyl, a radical COR3 in which R3 is a linear or branched C1-C8 alkyl radical, optionally substituted with at least one radical —OR and/or one radical —COOR and/or one radical —NHR and/or one radical —SR and/or one radical —R in which R is a hydrogen atom or a linear or branched C1-C4 alkyl radical, a benzenic or heterocyclic aralkyl or aryl radical optionally substituted with at least one radical —OR and/or one radical —COOR and/or one radical —NHR and/or one radical —SR and/or one radical —R in which R is a hydrogen atom or a linear or branched C1-C4 alkyl radical, formulated into a physiologically acceptable medium therefor.
A regime or regimen for treating a skin pathology characterized by the production of a thickened horny layer and by abnormal desquamation, comprising administering to an individual in need of such treatment, a thus effective amount of at least one 2-oxothiazolidine-4-carboxylic acid compound having the structural formula (I):
- 8
- in which X is —OH or —NHR2;
- and R1 and R2, which may be identical or different, are each a hydrogen atom, a linear or branched C1-C8 alkyl radical, optionally substituted with at least one radical —OR and/or one radical —COOR and/or one radical —NHR and/or one radical —SR and/or one radical —R in which R is a hydrogen atom or a linear or branched C1-C4 alkyl, a radical COR3 in which R3 is a linear or branched C1-C8 alkyl radical, optionally substituted with at least one radical —OR and/or one radical —COOR and/or one radical —NHR and/or one radical —SR and/or one radical —R in which R is a hydrogen atom or a linear or branched C1-C4 alkyl radical, a benzenic or heterocyclic aralkyl or aryl radical optionally substituted with at least one radical —OR and/or one radical —COOR and/or one radical —NHR and/or one radical —SR and/or one radical —R in which R is a hydrogen atom or a linear or branched C1-C4 alkyl radical, formulated into a physiologically acceptable medium therefor.
A cosmetic/therapeutic composition suited for promoting desquamation of the skin and/or stimulating epidermal renewal and/or combating skin aging, comprising (1) a thus effective amount of at least one 2-oxothiazolidine-4-carboxylic acid compound having the structural formula (I):
- 9
- in which X is —OH or —NHR2;
- and R1 and R2, which may be identical or different, are each a hydrogen atom, a linear or branched C1-C8 alkyl radical, optionally substituted with at least one radical —OR and/or one radical —COOR and/or one radical —NHR and/or one radical —SR and/or one radical —R in which R is a hydrogen atom or a linear or branched C1-C4 alkyl, a radical COR3 in which R3 is a linear or branched C1-C8 alkyl radical, optionally substituted with at least one radical —OR and/or one radical —COOR and/or one radical —NHR and/or one radical —SR and/or one radical —R in which R is a hydrogen atom or a linear or branched C1-C4 alkyl radical, a benzenic or heterocyclic aralkyl or aryl radical optionally substituted with at least one radical —OR and/or one radical —COOR and/or one radical —NHR and/or one radical —SR and/or one radical —R in which R is a hydrogen atom or a linear or branched C1-C4 alkyl radical, (2) an effective amount of at least one active agent selected from the group consisting of antibacterial agents, antiparasitic agents, antifungal agents, antiviral agents, anti-inflammatory agents, anti-pruriginous agents, anaesthetics, agents affecting the radiance of the complexion by promoting turnover and desquamation, free-radical scavengers, antiseborrhoeic agents, antidandruff agents, antiacne agents and/or agents for modifying skin differentiation and/or proliferation, depigmenting agents, extracts of plant, marine or bacterial origin, and mixtures thereof, and (3) a physiologically acceptable medium therefor.
A cosmetic/therapeutic composition suited for promoting desquamation of the skin and/or stimulating epidermal renewal and/or combating skin aging, comprising (1) a thus effective amount of at least one 2-oxothiazolidine-4-carboxylic acid compound having the structural formula (I):
- 10
- in which X is —OH or —NHR2;
- and R1 and R2, which may be identical or different, are each a hydrogen atom, a linear or branched C1-C8 alkyl radical, optionally substituted with at least one radical —OR and/or one radical —COOR and/or one radical —NHR and/or one radical —SR and/or one radical —R in which R is a hydrogen atom or a linear or branched C1-C4 alkyl, a radical COR3 in which R3 is a linear or branched C1-C8 alkyl radical, optionally substituted with at least one radical —OR and/or one radical —COOR and/or one radical —NHR and/or one radical —SR and/or one radical —R in which R is a hydrogen atom or a linear or branched C1-C4 alkyl radical, a benzenic or heterocyclic aralkyl or aryl radical optionally substituted with at least one radical —OR and/or one radical —COOR and/or one radical —NHR and/or one radical —SR and/or one radical —R in which R is a hydrogen atom or a linear or branched C1-C4 alkyl radical, (2) an effective amount of at least one other pro-desquamating agent, and (3) a physiologically acceptable medium therefor.
Dependencies are inferred from the claim text.