Potentiators of glutamate receptors

A compound of the formula

• 182
• wherein
• R1 is selected from the group consisting of —C(O)R3, —C(O)OR4, and —SO2R5
• wherein R3 is selected from the group consisting of alkyl and cycloalkyl, R4 is selected from the group consisting of alkyl and cycloalkyl, R5 is selected from the group consisting of alkyl, cycloalkyl, and fluorinated alkyl;
• R2 is from 1 to 3 substituents independently selected from the group consisting of hydrogen, hydroxy, trisubstituted silyloxy, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkoxy, substituted alkoxy, cycloalkoxy, substituted cycloalkoxy, cycloalkyl, substituted cycloalkyl, halogen, cyano, nitro, phenyl, substituted phenyl, pyridyloxy, thiophenoxy, substituted thiophenoxy, phenylsulfinyl, substituted phenylsulfinyl, phenylsulfonyl, substituted phenylsulfonyl, benzoyl, substituted benzoyl, phenoxy, and substituted phenoxy;
• or
• two R2 substituents are taken together, on adjacent positions, to form a fused cycloalkyl or a methylenedioxy ring, and one R2 substituent is selected from the group consisting of hydrogen, hydroxy, trisubstituted silyloxy, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkoxy, substituted alkoxy, cycloalkoxy, substituted cycloalkoxy, cycloalkyl, substituted cycloalkyl, halogen, cyano, nitro, phenyl, substituted phenyl, pyridyloxy, thiophenoxy, substituted thiophenoxy, phenylsulfinyl, substituted phenylsulfinyl, phenylsulfonyl, substituted phenylsulfonyl, benzoyl, substituted benzoyl, phenoxy, and substituted phenoxy;
• R6 is from 1 to 2 substituents independently selected from the group consisting of hydrogen, alkyl, alkoxy, trifluoromethyl, halogen, phenoxy, and substituted phenoxy;
• X is selected from the group consisting of a bond, —CH2—, —CHR7—, and —CH2CH2— wherein R7 is lower alkyl;
• Y is selected from the group consisting of a bond, —CH2—, —CHR8—, —CH2CH2—, —CHR9CH2—, and —CH2CHR9 wherein R8 is lower alkyl and R9 is lower alkyl;
• and the pharmaceutically acceptable salts thereof and the pyridyl N-oxides thereof.