Methods for nicotine replacement dosage determination
OwnerDavid P.L. Sachsinventor
Life of this patent
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Abstract
A method for predicting nicotine replacement dosage to achieve a target nicotine serum concentration relies on measuring blood nicotine concentration prior to smoking cessation. At least two values corresponding to other patient characteristics, such as body mass, cumulative smoking, psychological dependence, age, and menopausal status, are also determined and used to predict expected blood nicotine concentrations based on nicotine replacement dosages. Such methods are useful in achieving target blood nicotine concentrations for smoking cessation and therapy.
Claims24
A smoking cessation method, said method comprising:
- measuring a blood nicotine concentration while a patient is smoking;
- determining at least two values corresponding to patient characteristics selected from the group consisting of a body mass factor, a cumulative smoking factor, a psychological dependence factor, age, and menopausal status;
- and
- administering nicotine to the patient at an initial dosage determined based on said blood nicotine concentration and said at least two values.
A method for determining a relationship between nicotine dosage and nicotine serum concentration in a population of patients who smoke tobacco, said method comprising:
- measuring blood nicotine concentrations in individual patients in said population while said individuals are smoking;
- administering a known dosage of nicotine to the patient after the patient has stopped smoking;
- measuring blood nicotine concentrations in each individual patient while administering nicotine and while the patient refrains from smoking;
- determining at least two values corresponding to characteristics from each individual patient selected from the group consisting of a body mass factor, a cumulative smoking factor, a psychological dependence factor, age, and menopausal status;
- and
- determining a relationship between nicotine dosage and nicotine serum concentration as a function of blood nicotine concentration while smoking and said at least two patient characteristics.
Dependencies are inferred from the claim text.