US 2004/0006111 A1 · Transmucosal delivery of proton pump inhibitors

Abstract

The present invention relates to pharmaceutical compositions and methods for transmucosal delivery of proton pump inhibitors. In one embodiment, the pharmaceutical composition of the present invention comprises a core which comprises an antacid, and an outer layer surrounding the core. The outer layer contains a therapeutically effective amount of a proton pump inhibitor. In another embodiment, the pharmaceutical composition of the present invention comprises an outer layer which comprising a unidirectional film, and an inner layer which contains a therapeutically effective amount of a proton pump inhibitor. In yet another embodiment, the pharmaceutical composition of the present invention is a unidirectional tablet for delivery of a proton pump inhibitor across the oral mucosa. In this embodiment, the pharmaceutical composition contains an outer layer which contains a pharmaceutically acceptable water impermeable layer, and an inner layer which contains a therapeutically effective amount of a proton pump inhibitor.

Claims90

Dependent claims

A pharmaceutical composition comprising:

a core comprising an antacid;
and
an outer layer surrounding the core, said outer layer comprising a therapeutically effective amount of a proton pump inhibitor, or a pharmaceutically acceptable salt, prodrug, derivative, enantiomer, free base, isomer, polymorph, hydrate, anhydrate or solvate thereof.

Dependencies are inferred from the claim text.

Facts

Application

10/353,143Filed 27 Jan 2003

Priority

25 Jan 2002

Published

8 Jan 2004

Term ends

Not estimatedThe source records don’t support an estimate.

Classification10 codes

A61K 45/06
Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00: mixtures of active ingredients without…
A61K 9/006
Mouth and digestive tract, i.e. intraoral and peroral administration: oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or…
A61K 9/209
Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat: containing drug in at least two layers or in the core and in at…
A61K 31/4439
Containing further heterocyclic ring systems: containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole

Transmucosal delivery of proton pump inhibitors

Life of this patent

Transmucosal delivery of proton pump inhibitors

Life of this patent

Abstract

Claims90