Heteroaryl urea neuropeptide Y Y5 receptor antagonists

A compound of Formula I:

• 266
• or a pharmaceutically acceptable salt and/or hydrate of said compound,
• wherein
• ═A—B═ is ═C(R4)—C(R5)═ and —X═Y— is —C(R6)═N—, —N═C(R7)—, —N═N— or —S—, or
• ═A—B═ is ═N—C(R5)═ and —X═Y— is —N═C(R7)—, —C(R6)═N—, —S— or —O—, or
• ═A—B═ is ═C(R4)—N═ and —X═Y— is —C(R6)═N—, —S— or —O—, or
• ═A—B═ is ═N—N═ and —X═Y— is —S— or —O—, or
• ═A—B═ is ═C(R4)— and —X═Y— is —S—N═, —N(R10)—N═, or
• ═A—B═ is —C(R4)═ and —X═Y— is ═N—S—, or ═N—N(R10)—;
• Z is
• 267
• R1 is H or —(C1-C6)alkyl;
• R2 is H, —(C1-C6)alkyl, —(C3-C7)cycloalkyl or —(C1-C6)alkyl(C3-C7)cycloalkyl;
• 268
• Q is —OR13, or —NR13R14;
• j is 1 or 2;
• k is 0, 1 or 2;
• l is 0, 1 or 2;
• m is 0, 1 or 2;
• n is 0 to 6;
• p is 1, 2 or 3;
• q is 1 or 2;
• R4, R5, R6 and R7 may be the same or different, and are independently selected from H, —OH, halogen, haloalkyl, —(C1-C6)alkyl, —(C3-C7)cycloalkyl, —(C1-C6)alkyl(C3-C7)cycloalkyl, —CN, NR10R11, NR13R14, —O(C1-C6)alkyl, —O(C3-C7)cycloalkyl, —O(C1-C6)alkyl(C3-C7)cycolalkyl, —S(C1-C6)alkyl, —S(C3-C7)cycloalkyl and —S(C1-C6)alkyl(C3-C7)cycloalkyl;
• R8 may be the same or different, and is independently selected from H, halogen, —OH, haloalkyl, haloalkoxy, —CN, —NO2, —(C1-C6)alkyl, —(C3-C7)cycloalkyl, —(C1-C6)alkyl(C3-C7)cycloalkyl, NR10R11, NR13R14, —O(C1-C6)alkyl, —O(C3-C7)cycloalkyl, —O(C1-C6)alkyl(C3-C7)cycloalkyl and —CONR13R14;
• R9 is —SO2(C1-C6)alkyl, —SO2(C3-C7)cycloalkyl, —SO2(C1-C6)alkyl(C3-C7)cycloalkyl, —SO2(C1-C6)haloalkyl, —SO2[hydroxy(C2-C6)alkyl], —SO2[amino(C2-C6)alkyl], —SO2[alkoxy(C2-C6)alkyl], —SO2[alkylamino(C2-C6)alkyl], —SO2[dialkylamino(C2-C6)alkyl], —SO2(aryl), —SO2(heteroaryl), —SO2[aryl(C1-C6)alkyl], —SO2NR13R14, —CO(C1-C6)alkyl, —CO(C3-C7)cycloalkyl, —CO(C1-C6)alkyl(C3-C7)cycloalkyl, CO(C1-C6)haloalkyl, —C(O)aryl, —C(O)heteroaryl, —CONR13R14, —C(S)NR13R14, aryl, heteroaryl, —(CH2)CONR13R14, —C(═NCN)alkylthio, —C(═NCN)NR13R14, —(C1-C6)alkyl, —(C3-C7)cycloalkyl, —(C1-C6)alkyl(C3-C7)cycloalkyl, —(C1-C6)alkylaryl, —(C1-C6)alkylheteroaryl or —COOR12;
• R10 is H or alkyl;
• R11 is H, —(C1-C6)alkyl, —(C3-C7)cycloalkyl, —(C1-C6)alkyl(C3-C7)cycloalkyl, aryl, heteroaryl, —SO2(C1-C6)alkyl, —SO2(C3-C7)cycloalkyl, —SO2(C1-C6)alkyl(C3-C7)cycloalkyl, —SO2(C1-C6)haloalkyl, —SO2(aryl), —SO2(heteroaryl), —CO(C1-C6)alkyl, —CO(C3-C7)cycloalkyl, —CO(C1-C6)alkyl(C3-C7)cycloalkyl, —C(O)aryl, —C(O)heteroaryl, —CONR13R14 or —COOR12;
• R12 is —(C1-C6)alkyl, —(C3-C7)cycloalkyl, —(C1-C6)alkyl(C3-C7)cycloalkyl, —(C1-C6)alkylaryl, —(C1-C6)alkylheteroaryl, aryl or heteroaryl;
• R13 and R14 may be the same or different and are independently H, —(C1-C6)alkyl, —(C3-C7)cycloalkyl, —(C1-C6)alkyl(C3-C7)cycloalkyl, —(C1-C6)alkylaryl, aryl or heteroaryl;
• and,
• R15 may be the same or different, and is H, —(C1-C6)alkyl, —(C3-C7)cycloalkyl, —(C1-C6)alkyl(C3-C7)cycloalkyl, aryl, heteroaryl, —CN, —CONR13R14, —COOR13, —OH, —O(C1-C6)alkyl, —O(C3-C7)cycloalkyl, —O(C1-C6)alkyl(C3-C7)cycloalkyl, —NR10R11, —NR13R14, or a —(C1-C6)alkyl group substituted by an aryl, heteroaryl, hydroxy, alkoxy, —NR10R11, —NR13R14, —CONR13R14, or —COOR13 group.