Hydroxyalkanoyl aminopyrazoles and related compounds

A compound of Formula I:

• 32
• or a pharmaceutically acceptable salt form or prodrug thereof,
• wherein X is selected from the group consisting of:
• 33 34 35 36 37
• Q is Q1,
• (C1-C3 alkyl)-O-Q1,
• (C1-C3 alkyl)-S-Q1,
• (C1-C3 alkyl)-S(═O)-Q1,
• (C1-C3 alkyl)-S(═O)2-Q1, or
• (C1-C3 alkyd)-N(R20)-Q1;
• Q1, R10, and R11 are independently C1-C6 alkyl substituted with 0-3 R1a;
• C2-C6 alkenyl substituted with 0-3 R1a;
• C2-C6 alkynyl substituted with 0-3 R1a;
• C3-C10 cycloalkyl substituted with 0-3 R1b;
• C3-C10 carbocycle substituted with 0-3 R1b;
• C6-C10 aryl substituted with 0-3 R1b;
• or
• 5 to 10 membered heterocycle containing 1 to 4 heteroatoms selected from nitrogen, oxygen, alnd sulphur, wherein said 5 to 10 membered heterocycle is substituted with 0-3 R1b;
• R1a, at each occurrence, is independently selected from the group consisting of:
• H, C1-C6 alkyl, OR14, Cl, F, Br, I, NR15R16,CF3;
• C3-C10 carbocycle substituted with 0-3 R1b;
• C6-C10 aryl substituted with 0-3 R1b;
• and
• 5 to 10 membered heterocycle containing 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulphur, wherein said 5 to 10 membered heterocycle is substituted with 0-3 R1b;
• R2 and R12 are independently H, methyl, ethyl, propyl, or butyl;
• R3 is H, C1-C4 alkyl, —C(═O)(C1-C4 alkyl), —C(═S)(C1-C4 alkyl), or —C(═O)NR21R22;
• R5 is H, OR14;
• C1-C6 alkyl substituted with 0-3 R5b;
• C1-C6 alkoxy substituted with 0-3 R5b;
• C2-C6 alkenyl substituted with 0-3 R5b;
• C2-C6 alkynyl substituted with 0-3 R5b;
• C3-C10 cycloalkyl substituted with 0-3 R5c;
• C3-C10 carbocycle substituted with 0-3 R5c;
• C6-C10 aryl substituted with 0-3 R5c;
• or
• 5 to 10 membered heterocycle containing 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulphur, wherein said 5 to 10 membered heterocycle is substituted with 0-3R5c;
• R5a is H, C1-C4 alkyl, or C2-C4 alkenyl;
• or, R5 and R5a is combined to form a 3-7 membered cycloalkyl ring substituted with 0-3 R5c;
• R5b, at each occurrence, is independently selected from the group consisting of:
• H, C1-C6 alkyl, CF3, OR14, Cl, F, Br, I, ═O, CN,NO2, NR15R16, acetyl, SCH3, S(═O)CH3, S(═O)2CH3, C2-C6 alkenyl, C2-C6 alkynyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, and C1-C4 haloalkyl-S—,
• C3-C10 cycloalkyl substituted with 0-3 R5c;
• C3-C10 carbocycle substituted with 0-3 R5c;
• C6-C10 aryl substituted with 0-3 R5c;
• and
• 5 to 10 membered heterocycle containing 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulphur, wherein said 5 to 10 membered heterocycle is substituted with 0-3 R5c;
• R5c, at each occurrence, is independently selected from the group consisting of H, OH, Cl, F, Br, I, CN, NO2, NR15R16, CF3, acetyl, SCH3, S(═O)CH3, S(═O)CH3, C1-C6 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, and C1-C4 haloalkyl-S—;
• R13, at each occurrence, is independently C1-C6 alkyl, alkeny, or alkynyl optionally substituted with C6-C10 aryl substituted with 0-3 R5c;
• R14, at each occurrence, is independently selected from the group consisting of H, phenyl, benzyl, C1-C6 alkyl, and C2-C6 alkoxyalkyl;
• R15, at each occurrence, is independently selected from the group consisting of H, C1-C6 alkyl, phenyl, benzyl, phenethyl, (C1-C6 alkyl)-C(═O)—, (C1-C6 alkyl)-O—C(═O)— and (C1-C6 alkyl)-S(═O)2—;
• R16, at each occurrence, is independently selected from the group consisting of H, C1-C6 alkyl, phenyl, benzyl, phenethyl, (C1-C6 alkyl)-C(═O)—, (C1-C6 alkyl)-O—C(═O)— and (C1-C6 alkyl)-S(═O)2—.