Cephalotaxanes, their method of preparation and their use in treatment of cancers, leukemias, parasites including those resistant to usual chemotherapeutic agents and as reversal agents

A compound of formula (I)

• 120
• wherein,
• W is O or NH;
• Q is an unbranched or branched, saturated or unsaturated or aromatic, cyclic or acyclic or heterocyclic hydrocarboned radical containing 1 to 30 carbon atoms, optionally comprising heteroatom(s);
• R1 is H, OH, OMe, O—(C1-C30)-alkyl, O-aryl-(C1-C30)-alkyl, O—(C2-C30)-alkenyl, O—(C3-C30)-cycloalkyl or null, and R2 is H or OH, or R1 and R2 together form —O—;
• R3 and R4 are OMe, or R3 and R4 together form —OCH2O—;
• R is H, C1-C30-alkyl or O-protecting group, and
• R6 is an unbranched or branched, saturated or unsaturated or aromatic, cyclic or acyclic or heterocyclic hydrocarboned radical containing 1 to 30 carbon atoms, optionally including heteroatom(s), or R and R6 together form —CMe2—;
• n=0 to 8;
• R5 is H, OH, OMe, O—(C1-C30)-alkyl, O-aryl-(C1-C30)-alkyl, O—(C2-C30)-alkenyl, O—(C3-C30)-cycloalkyl or O-aryl;
• and
• the dotted line is null or forms a double bond depending on the meaning of R1;
• except for compounds wherein:
• W is O, the dotted line forms a double bond, R1 is null, R2 is H, R3 and R4 together form —O—CH2—O—, R5 is OMe, Q is CO2R7, and
• R is H, R6 is —(C—OH)Me2, n=2 or 3, R7 is H;
• R is H, R6 is —(C—H)Me2, n=2 to 4, R7 is Me;
• R is H, R6 is —(C—H)Me2, n=1 or 2, R7 is H;
• R is H, R6 is Ph, n=1 to 3, R7 is Me;
• R is H, R6 is —CH═Ch-Ph, n=0, R7 is Me;
• R is H, R6 is CH3, n=4, R7is Me;
• R and R6 together form —CMe2-, n=2 or 3, R7 is Me;
• W is O, the dotted line forms a double bond, R1 is null, R2 is OH, R3 and R4 together form —O—CH2—O—, R5 is OMe, and R is H, R6 is —(C—H)Me2, n=2 or 3, R7 is Me;
• and
• W is O, the dotted line is null, R1 and R2 together form —O—, R3 and R4 together form —O—CH2—O—, R6 is OMe, and R is H, R6 is —(C—H)Me2, n=2, R7 is Me.