Substituted alkanoic acids

A compound of general formula (I):-

• 188
• wherein:-
• 189
• represents (i) a saturated 3- to 6-membered carbocycle, optionally substituted by one or more alkyl groups, (ii) indanyl or (iii) a saturated 4- to 6-membered heterocyclic ring;
• R1 represents R3Z1-Het- or R4N(R5)—C(═O)—NH—Ar1—;
• R2 represents hydrogen, halogen, lower alkyl or lower alkoxy;
• Het represents a saturated, partially saturated or fully unsaturated 8 to 10 membered bicyclic ring system containing at least one heteroatom selected from O, S or N, optionally substituted by one or more aryl group substituents;
• R3 represents optionally substituted aryl or optionally substituted heteroaryl;
• R4 represents hydrogen or lower alkyl and R5 represents optionally substituted aryl, arylalkyl, heteroaryl or heteroarylalkyl;
• or
• R4 and R5 together with the nitrogen atom to which they are attached form a cyclic amine;
• R6 is a direct bond or a straight or branched alkylene chain, alkenylene chain or alkynylene chain;
• R7 is a direct bond, cycloalkylene, heterocycloalkylene, aryldiyl, heteroaryldiyl, —C(═Z2)—NR8—, —NR8—C(═Z2)—, —Z2—, —C(═O)—, —C(═NOR8)—, —NR8—, —NR8—C(═Z2)—NR8—, —SO2—NR8—, —NR8—SO2—, —O—C(═O)—, —C(═O)—O—, —NR8—C(═O)—O— or —O—C(═O)—NR8—;
• or
• R6 and R7 together represent a direct bond;
• R8 represents hydrogen or lower alkyl;
• Ar1 represents optionally substituted aryldiyl or heteroaryldiyl;
• L1 represents an —R6—R7— linkage;
• L2 represents an alkylene linkage;
• Y is carboxy or an acid bioisostere;
• Z1 represents NH;
• Z2 is O or S;
• and the corresponding N-oxides and ester prodrugs of such compounds;
• and pharmaceutically acceptable salts and solvates of such compounds and their N-oxides and ester prodrugs, but excluding compounds where an oxygen, nitrogen or sulfur atom is attached directly to a carbon-carbon multiple bond of an alkenylene or alkynylene residue.