Methods, pharmaceutical compositions and pharmaceutical kits for enhancing the therapeutic efficiency of cancer chemotherapeutic agents
AssigneeRamot University Authority for Applied Research and Industrial Development Ltd.
InventorsRimona Margalit, Dan Peer
Life of this patent
Estimating the term…
Abstract
A pharmaceutical composition which comprises a chemotherapeutically effective amount of one or more chemotherapeutic agent(s), being entrapped in a drug carrier, and a chemosensitizing effective amount of one or more chemosensitizing agent(s) and/or a chemoprotecting effective amount of one or more chemoprotecting agent(s) and methods of using same in cancer therapy.
Claims166
A pharmaceutical composition comprising:
- a chemotherapeutically effective amount of at least one chemotherapeutic agent, said at least one chemotherapeutic agent being entrapped in a drug carrier;
- and
- a chemosensitizing effective amount of at least one chemosensitizing agent.
A pharmaceutical composition comprising:
- a chemotherapeutically effective amount of at least one chemotherapeutic agent, said at least one chemotherapeutic agent being entrapped in a drug carrier;
- a chemosensitizing effective amount of at least one chemosensitizing agent;
- and
- a chemoprotective effective amount of at least one chemoprotecting agent.
A pharmaceutical composition comprising:
- a chemotherapeutically effective amount of at least one chemotherapeutic agent, said at least one chemotherapeutic agent being entrapped in a drug carrier;
- and
- a chemoprotective amount of at least one chemoprotecting agent.
A pharmaceutical kit comprising, as a chemotherapeutically active ingredient, at least one chemotherapeutic agent being entrapped in a drug carrier, and at least one chemosensitizing agent, wherein said at least one chemotherapeutic agent and said at least one chemosensitizing agent are individually packaged within the pharmaceutical kit.
A pharmaceutical kit comprising, as a chemotherapeutically active ingredient, at least one chemotherapeutic agent being entrapped in a drug carrier, and at least one chemoprotecting agent, wherein said at least one chemotherapeutic agent and said at least one chemoprotecting agent are individually packaged within the pharmaceutical kit.
A pharmaceutical kit comprising, as a chemotherapeutically active ingredient, at least one chemotherapeutic agent being entrapped in a drug carrier, at least one chemosensitizing agent and at least one chemoprotecting agent, wherein said at least one chemotherapeutic agent, said at least one chemosensitizing agent and said at least one chemoprotecting agent are individually packaged within the pharmaceutical kit.
A method of treating cancer in a subject in need thereof, the method comprising:
- administering to said subject a chemotherapeutically effective amount of at least one chemotherapeutic agent being entrapped in a drug carrier;
- and
- administering to said subject a chemosensitizing effective amount of at least one chemosensitizing agent.
A method of treating cancer cells in an subject, the method comprising:
- administering to said subject a chemotherapeutically effective amount of at least one chemotherapeutic agent being entrapped in a drug carrier;
- administering to said subject a chemosensitizing effective amount of at least one chemosensitizing agent;
- and
- administering to said subject a chemoprotective effective amount of at least one chemoprotective agent.
A method of treating cancer in a subject in need thereof, the method comprising:
- administering to said subject a chemotherapeutically effective amount of at least one chemotherapeutic agent being entrapped in a drug carrier;
- and
- administering to said subject a chemoprotective effective amount of at least one chemoprotecting agent.
A method chemosensitizing cancer cells in a subject in need thereof, the method comprising administering to the subject a chemosensitizing effective amount of Lithium.
A method chemosensitizing MDR cancer cells in a subject in need thereof, the method comprising administering to the subject a chemosensitizing effective amount of Lithium.
A method of treating cancer in a subject in need thereof, the method comprising administering to the subject a chemosensitizing effective amount of Lithium and a chemotherapeutically effective amount of a chemotherapeutic agent.
A method of treating MDR cancer in a subject in need thereof, the method comprising administering to the subject a chemosensitizing effective amount of Lithium and a chemotherapeutically effective amount of a chemotherapeutic agent.
A pharmaceutical composition for treating cancer comprising, as a chemosensitizing agent a chemosensitizing effective amount of Lithium and a chemotherapeutically effective amount of a chemotherapeutic agent.
A pharmaceutical composition for treating MDR cancer comprising, as a chemosensitizing agent a chemosensitizing effective amount of Lithium and a chemotherapeutically effective amount of a chemotherapeutic agent.
A pharmaceutical composition for chemosensitizing cancer cells in a subject in need thereof, comprising, as a chemosensitizing agent, a chemosensitizing effective amount of Lithium, the pharmaceutical composition is packaged in a package and is identified in print in or on said package for use in chemosensitizing.
A pharmaceutical kit comprising, as a chemotherapeutically active ingredient, at least one chemotherapeutic agent, and Lithium, wherein said at least one chemotherapeutic agent and said Lithium are individually packaged within the pharmaceutical kit.
Dependencies are inferred from the claim text.