Method for the identification and treatment of pathogenic microorganism infections by inhibiting one or more enzymes in an essential metabolic pathway and compounds and pharmaceutical compositions useful therefor
AssigneePyro Pharmaceuticals, Inc.
InventorAlan M. Schechter
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Abstract
A method for the identification and treatment of pathogenic microorganism infections by inhibiting one or more enzymes in a metabolic pathway by inhibiting the conversion of substrate to produce the penultimate or ultimate product particularly by inhibiting the activity of one or more of the enzymes in the pathway, and compounds and pharmaceutical compositions for inhibiting infections of pathogenic microorganisms by inhibiting such enzymes.
Claims30
A method of treating a microorganism infection in a patient which comprises administering to said patient an effective amount of a compound capable of inhibiting an enzyme that is important in (a) glucose metabolism (b) Coenzyme A (CoA) biosynthesis, (c) biotin metabolism, (d) reductive carboxylation, (e) riboflavin biosynthesis or (f) thiamine biosynthesis in said microorganism.
A method of identifying a compound capable of inhibiting the growth of pathogenic microorganisms in a mammalian patient, which comprises:
- a) identifying an enzyme that is important to glucose metabolism, Coenzyme A (CoA) biosynthesis, biotin metabolism, reductive carboxylation, riboflavin biosynthesis or thiamine in biosynthesis in said pathogenic microorganism, which enzyme is not present in said mammalian patient;
- and
- b) identifying a compound that inhibits said enzyme in said pathogenic microorganism.
Dependencies are inferred from the claim text.