US 2004/0006039 A1 · Neutral sphingomyelinase antisense ribozyme and uses thereof

Abstract

The present invention provides novel antisense ribozymes useful for inhibiting the activity of neutral sphingomyelinase. Also provided are methods for reducing the activity of neutral sphingomyelinase, as well as methods for reducing apoptosis and atherosclerosis using the ribozymes of the invention.

Claims15

Dependent claims

A nucleic acid molecule comprising a ribozyme which is specific for N-SMase mRNA.

Dependencies are inferred from the claim text.

Facts

Application

10/446,519Filed 27 May 2003

Priority

23 Oct 2001

Published

8 Jan 2004

Term ends

Not estimatedThe source records don’t support an estimate.

Classification10 codes

C12N 15/1137
Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming…: against enzymes
C07H 21/04
Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of…: with…
C12Y 301/04012
Phosphoric diester hydrolases: sphingomyelin phosphodiesterase
A61K 38/00
Medicinal preparations containing peptides

Family

Application60/342,631Us provisional application · filed 23 Oct 2001

Application10/279,215Continuation in part · filed 23 Oct 2002

Application10/446,519Continuation in part · filed 27 May 2003

US 7,230,094 B2Related patent

US 2004/0006039 A1This patent

From the US filing history. Foreign family members aren’t listed.

Abstract

Facts

Application

10/446,519Filed 27 May 2003

Priority

23 Oct 2001

Published

8 Jan 2004

Term ends

Not estimatedThe source records don’t support an estimate.

Classification10 codes

C12N 15/1137
Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming…: against enzymes
C07H 21/04
Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of…: with…
C12Y 301/04012
Phosphoric diester hydrolases: sphingomyelin phosphodiesterase
A61K 38/00
Medicinal preparations containing peptides

Family

Application60/342,631Us provisional application · filed 23 Oct 2001

Application10/279,215Continuation in part · filed 23 Oct 2002

Application10/446,519Continuation in part · filed 27 May 2003

US 7,230,094 B2Related patent

US 2004/0006039 A1This patent

From the US filing history. Foreign family members aren’t listed.

Neutral sphingomyelinase antisense ribozyme and uses thereof

Life of this patent

Abstract

Claims15

Neutral sphingomyelinase antisense ribozyme and uses thereof

Life of this patent

Abstract

Claims15