Antisense modulation of HMG-CoA reductase expression
AssigneeIsis Pharmaceuticals, Inc.
InventorsNicholas M. Dean, Susan M. Freier, Kenneth W. Dobie
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Abstract
Antisense compounds, compositions and methods are provided for modulating the expression of HMG-CoA reductase. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding HMG-CoA reductase. Methods of using these compounds for modulation of HMG-CoA reductase expression and for treatment of diseases associated with expression of HMG-CoA reductase are provided.
Claims20
A compound 8 to 80 nucleobases in length targeted to a nucleic acid molecule encoding HMG-CoA reductase, wherein said compound specifically hybridizes with said nucleic acid molecule encoding HMG-CoA reductase and inhibits the expression of HMG-CoA reductase.
A compound 8 to 80 nucleobases in length which specifically hybridizes with at least an 8-nucleobase portion of a preferred target region on a nucleic acid molecule encoding HMG-CoA reductase.
A method of screening for an antisense compound, the method comprising the steps of:
- a. contacting a preferred target region of a nucleic acid molecule encoding HMG-CoA reductase with one or more candidate antisense compounds, said candidate antisense compounds comprising at least an 8-nucleobase portion which is complementary to said preferred target region, and
- b. selecting for one or more candidate antisense compounds which inhibit the expression of a nucleic acid molecule encoding HMG-CoA reductase.
Dependencies are inferred from the claim text.