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US 2004/0006025 A1Published application
Pyrazole derivatives and diabetic medicine containing them
AssigneeAjinomoto Co., Inc.
InventorsKoji Ohsumi, Takashi Umemura, Hiroyuki Matsueda, Toshihiro Hatanaka, Akiko Onuki, Katsumi Maezono, Yoko Kageyama, Nobuo Kondo
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Abstract
The present invention provides pyrazole-O-glycoside derivatives represented by the following formulae, used as a diabetic medicine. 1
Claims22
Pyrazole derivatives of the following general formula (1A) or (1B) or pharmaceutically acceptable salts thereof:
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- wherein X represents a β-D-glucopyranosyl group, of which one or more hydroxyl groups may be acylated or β-D-glucuronyl group, of which one or more hydroxyl groups may be acylated and carboxyl group may be esterified;
- Y represents a lower alkyl group or perfluoro lower alkyl group;
- Z represents a hydrogen atom, lower alkyl group, perfluoro lower alkyl group, aralkyl group or phenyl group;
- R1 to R5 may be the same or different and represent a hydrogen atom, lower alkyl group, perfluoro lower alkyl group, lower alkoxy group, perfluoro lower alkoxy group, lower alkylthio group, perfluoro lower alkylthio group, lower alkyl amino group, halogeno group, lower alkanoyl group, lower alkenyl group or lower alkynyl group, and n represents an integer from 0 to 3.
2 more elements
Dependencies are inferred from the claim text.