Immunostimulatory polynucleotide/immunomodulatory molecule conjugates
AssigneeThe Regents of the University of California
InventorsDennis A. Carson, Eyal Raz, Mark Roman
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Abstract
Immunostimulatory polynucleotide-immunomodulatory molecule conjugate compositions are disclosed. These compositions include a polynucleotide that is linked to an immunomodulatory molecule, which molecule comprises an antigen and may further comprise immunomodulators such as cytokines and adjuvants. The polynucleotide portion of the conjugate includes at least one immunostimulatory oligonucleotide nucleotide sequence (ISS). Methods of modulating an immune response upon administration of the polynucleotide-immunomodulatory conjugate preparation to a vertebrate host are also disclosed.
Claims119
An immunomodulatory composition comprising an immunomodulatory molecule, which molecule comprises an antigen, conjugated to an polynucleotide that contains at least one immunostimulatory nucleotide sequence (ISS).
An immunomodulatory composition comprising an immunomodulatory molecule, which molecule comprises an antigen and an immunostimulatory peptide, conjugated to an polynucleotide that contains at least one ISS.
A method of modulating an immune response comprising the administration of an immunomodulatory composition comprising an immunomodulatory molecule, which molecule comprises an antigen, conjugated to an polynucleotide that contains at least one ISS.
A method of modulating an immune response comprising the administration of an immunomodulatory composition comprising an immunomodulatory molecule, which molecule is comprised of an antigen and an immunostimulatory peptide, conjugated to an polynucleotide that contains at least one ISS.
A method for introducing a soluble antigen into the Class I MHC processing pathway of the mammalian immune system to elicit a CTL response to the antigen comprising administering a polynucleotide conjugated to an immunomodulatory molecule, which molecule comprises the antigen, to a mammalian host.
A composition for introducing a soluble antigen into the Class I MHC processing pathway of the mammalian immune system to elicit a CTL response to the antigen comprising a polynucleotide conjugated to an immunomodulatory molecule, which molecule comprises the antigen.
Dependencies are inferred from the claim text.