Polypeptide derivatives and nucleic acid carriers containing the same
OwnerTakeshi Goto, Masaru Nakanishi +4inventors
InventorsTakeshi Goto, Masaru Nakanishi, Keishi Yonemura, Naoya Oomori, Takashi Yasukouchi, Masanao Oya
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Abstract
There are disclosed polypeptide derivatives and their pharmaceutically acceptable salts represented by formula (1), as well as their utility as nucleic acid carriers in gene therapy. 1
Claims10
A peptide derivative represented by formula (1):
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- wherein R1 is derived from one member selected from the group consisting of a monosaccharide, an oligosaccharide, a polysaccharide, a peptide, an oligopeptide, a polypeptide, an antibody and a cell-specific ligand, or is selected from the group consisting of an optionally substituted C1-C20 alkyl, an optionally substituted C1-C20 alkenyl, an optionally substituted C7-C45 aryl, an optionally substituted C7-C45 alkylaryl, an optionally substituted C7-C45 alkenylaryl, and an optionally substituted amino group wherein the substituent may be a moiety of the one member selected from the group consisting of a monosaccharide, an oligosaccharide, a polysaccharide, a peptide, an oligopeptide, a polypeptide, an antibody and a cell-specific ligand;
- “p” represents an integer of 1-5;
- “m” represents an integer of 2 or more;
- and “n” represents an integer of 2 or more, provided that “m+n” represents an integer of 300 or less,
- or a pharmaceutically acceptable salt thereof.
A method of selectively protecting the 4-amino group of diaminobutyric acid with a carbobenzoxy group, comprising reacting diaminobutyric acid or a acid addition salt thereof with [p-(benzyloxycarbonyl)phenyl]dimethylsulfonium methylsulfate in a reaction inert medium at a pH of from 8 to 11.
Dependencies are inferred from the claim text.