Targeting proteins to deliver therapeutic or diagnostic reagents
AssigneeBoard of Regents, The University of Texas System
InventorsMien-Chie Hung, Keng-Li Lan, Keng-Hsin Lan, Jaw-Ching Liu, Fu Ou-Yang
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Abstract
The present invention is directed to compositions comprising an angiogenesis inhibitor coupled to a therapeutic or diagnostic agent. In a specific embodiment, the composition is a fusion gene or fusion gene product encoding the angiogenesis inhibitor coupled to a therapeutic or diagnostic agent. In a particular embodiment, the composition is used for methods to treat angiogenesis-related diseases, such as cancer.
Claims40
A polypeptide comprising an antiangiogenesis polypeptide region linked to a therapeutic protein or polypeptide region or a diagnostic protein or polypeptide region.
A method comprising contacting a cell with a polypeptide comprising an antiangiogenesis polypeptide region linked to a therapeutic protein or polypeptide region or a diagnostic protein or polypeptide region.
A method of treating or diagnosing cancer comprising:
- obtaining a polypeptide comprising an antiangiogenesis polypeptide region linked to a therapeutic protein or polypeptide region or a diagnostic protein or polypeptide region or a nucleic acid encoding a polypeptide comprising an antiangiogenesis polypeptide region linked to a therapeutic protein or polypeptide region or a diagnostic protein or polypeptide region;
- and
- administering the polypeptide or nucleic acid encoding the polypeptide to a patient.
A nucleic acid encoding a polypeptide comprising an antiangiogenesis polypeptide region linked to a therapeutic protein or polypeptide region or a diagnostic protein or polypeptide region.
Dependencies are inferred from the claim text.