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AssigneeNPS Allelix Corp.
InventorsKaare M. Gautvik, Peter Alestrom, Tordis Beate Oyen, Odd Stokke Gabrielsen
Estimating the term…
The invention provides recombinant plasmids containing in DNA sequences coding for human preproparathyroid hormone. The invention further provides microorganisms, for example E. coli, transformed by these plasmids. The invention also provides a plasmid for insertion into yeast and a transformed yeast in which the plasmid contains DNA coding for parathyroid hormone. Parathyroid hormone is then secreted by the transformed yeast. Further the invention provides alternate polypeptides having parathyroid hormone activity, including PTH analogs, fragments and extensions, and provides alternate leader sequences and secretion signal sequences which can be used in the present invention. Finally, there are provided methods for purification of the secreted PTH hormone and/or derivatives.
Essentially pure recombinant hPTH.
Substantially pure synthetic hPTH.
Substantially pure recombinant hPTH.
Substantially pure recombinant hPTH which is resistant to degradation by a KEX2 like proteolytic enzyme.
A substantially pure hPTH derivative which is both intact and exhibits native biological activity.
A substantially pure hPTH derivative which is resistant to degradation by a KEX2 like proteolytic enzyme and which is both intact and exhibits native biological activity.
A genetically engineered microorganism capable of expressing an intact hPTH.
A substantially pure intact hPTH, obtained by expression and secretion of said hPTH from a genetically engineered microorganism.
A substantially pure intact hPTH derivative, obtained by expression and secretion of said hPTH from a genetically engineered microorganism.
Dependencies are inferred from the claim text.