Methods and reagents for modulating cholesterol levels
OwnerMichael R. Hayden, Angela R. Brooks-Wiison +1inventors
InventorsMichael R. Hayden, Angela R. Brooks-Wiison, Simon N. Pimstone
Life of this patent
Estimating the term…
Abstract
The invention features ABC1 nucleic acids and polypeptides for the diagnosis and treatment of abnormal cholesterol regulation. The invention also features methods for identifying compounds for modulating cholesterol levels in an animal (e.g., a human).
Claims65
An isolated ABCA1 polypeptide having ABCA1 biological activity and comprising an amino acid sequence with at least 50% identity to SEQ ID NO:
- 1.
The isolated ABCA1 polypeptide of claim 19 wherein said lipid is member selected from the group consisting of cholesterol and phospholipid.
An isolated ABCA1 polypeptide comprising amino acids 1 to 60 of SEQ ID NO:
- 1.
An isolated ABCA1 polypeptide comprising amino acids 61 to 2261 of SEQ ID NO:
- 1.
An isolated ABCA1 polypeptide comprising amino acids 1 to 2261 of SEQ ID NO:
- 1.
An isolated polynucleotide comprising a nucleotide sequence having at least 50% identity to SEQ ID NO:
- 1 and that encodes an ABCA1 polypeptide having ABCA1 biological activity.
A substantially pure polynucleotide comprising at least thirty consecutive nucleotides contained in nucleotides 7015-7860 of SEQ ID NO:
- 2.
A substantially pure polynucleotide that hybridizes at high stringency to a probe comprising nucleotides 7015-7860 of SEQ ID NO:
- 2.
An oligonucleotide comprising nucleotides 75 to 254 of SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.