Secreted and transmembrane polypeptides and nucleic acids encoding the same
OwnerLuc Desnoyers, Audrey Goddard +5inventors
InventorsLuc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, Jennie P. Mather, P. Mickey Williams, William I. Wood
Life of this patent
Estimating the term…
Abstract
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
Claims38
Isolated nucleic acid having at least 80% sequence identity to a nucleotide sequence that encodes a polypeptide comprising an amino acid sequence selected from the group consisting of the amino acid sequence shown in FIG. 2 (SEQ ID NO:
- 2), FIG. 4 (SEQ ID NO:
- 4), FIG. 6 (SEQ ID NO:
- 12), FIG. 9 (SEQ ID NO:
- 18), FIG. 11 (SEQ ID NO:
- 23), FIG. 13 (SEQ ID NO:
- 28), FIG. 15 (SEQ ID NO:
- 34), FIG. 17 (SEQ ID NO:
- 39), FIG. 19 (SEQ ID NO:
- 49), FIG. 22 (SEQ ID NO:
- 59), FIG. 24 (SEQ ID NO:
- 64), FIG. 26 (SEQ ID NO:
- 69), FIG. 28 (SEQ ID NO:
- 71), FIG. 30 (SEQ ID NO:
- 73), FIG. 32 (SEQ ID NO:
- 84), FIG. 34 (SEQ ID NO:
- 91), FIG. 36 (SEQ ID NO:
- 96), FIG. 38 (SEQ ID NO:
- 104), FIG. 40 (SEQ ID NO:
- 109), FIG. 42 (SEQ ID NO:
- 114), FIG. 44 (SEQ ID NO:
- 119), FIG. 46 (SEQ ID NO:
- 127), FIG. 48 (SEQ ID NO:
- 132), FIG. 50 (SEQ ID NO:
- 137), FIG. 52 (SEQ ID NO:
- 142), FIG. 54 (SEQ ID NO:
- 148), FIG. 56 (SEQ ID NO:
- 153), FIG. 58 (SEQ ID NO:
- 159), FIG. 60 (SEQ ID NO:
- 164), FIG. 62 (SEQ ID NO:
- 170), FIG. 64 (SEQ ID NO:
- 175), FIG. 66 (SEQ ID NO:
- 177), FIG. 68 (SEQ ID NO:
- 185), FIG. 70 (SEQ ID NO:
- 190), FIG. 72 (SEQ ID NO:
- 195), FIG. 74 (SEQ ID NO:
- 201), FIG. 76 (SEQ ID NO:
- 207), FIG. 78 (SEQ ID NO:
- 213), FIG. 80 (SEQ ID NO:
- 221), FIG. 82 (SEQ ID NO:
- 227), FIG. 84 (SEQ ID NO:
- 236), FIG. 86 (SEQ ID NO:
- 245), FIG. 88 (SEQ ID NO:
- 250), FIG. 90 (SEQ ID NO:
- 255), FIG. 92 (SEQ ID NO:
- 257), FIG. 94 (SEQ ID NO:
- 259), FIG. 96 (SEQ ID NO:
- 261), FIG. 98 (SEQ ID NO:
- 263), FIG. 100 (SEQ ID NO:
- 285), FIG. 102 (SEQ ID NO:
- 290), FIG. 104 (SEQ ID NO:
- 292), FIG. 106 (SEQ ID NO:
- 294), FIG. 108 (SEQ ID NO:
- 310), FIG. 110 (SEQ ID NO:
- 315), FIG. 112 (SEQ ID NO:
- 320), FIG. 114 (SEQ ID NO:
- 325), FIG. 116 (SEQ ID NO:
- 332), FIG. 118 (SEQ ID NO:
- 339), FIG. 120 (SEQ ID NO:
- 341), FIG. 122 (SEQ ID NO:
- 377) and FIG. 124 (SEQ ID NO:
- 423).
Isolated nucleic acid which comprises the full-length coding sequence of the DNA deposited under accession number ATCC 209258, ATCC 209256, ATCC 209264, ATCC 209250, ATCC 209375, ATCC 209378, ATCC 209384, ATCC 209396, ATCC 209420, ATCC 209480, ATCC 209265, ATCC 209257, ATCC 209262, ATCC 209253, ATCC 209402, ATCC 209401, ATCC 209397, ATCC 209400, ATCC 209385, ATCC 209367, ATCC 209432, ATCC 209263, ATCC 209251, ATCC 209255, ATCC 209252, ATCC 209373, ATCC 209370, ATCC 209523, ATCC 209372, ATCC 209374, ATCC 209373, ATCC 209382, ATCC 209383, ATCC 209403, ATCC 209398, ATCC 209399, ATCC 209392, ATCC 209387, ATCC 209388, ATCC 209394, ATCC 209421, ATCC 209393, ATCC 209418, ATCC 209485, ATCC 209483, ATCC 209482, ATCC 209491, ATCC 209481, ATCC 209438, ATCC 209927, ATCC 209439, ATCC 209489, ATCC 209433, ATCC 209488, ATCC 209434, ATCC 209395, ATCC 209486, ATCC 209490, ATCC 209484, ATCC 209371 or ATCC 203553.
Isolated native sequence PRO polypeptide having at least 80% sequence identity to an amino acid sequence selected from the group consisting of the amino acid sequence shown in FIG. 2 (SEQ ID NO:
- 2), FIG. 4 (SEQ ID NO:
- 4), FIG. 6 (SEQ ID NO:
- 12), FIG. 9 (SEQ ID NO:
- 18), FIG. 11 (SEQ ID NO:
- 23), FIG. 13 (SEQ ID NO:
- 28), FIG. 15 (SEQ ID NO:
- 34), FIG. 17 (SEQ ID NO:
- 39), FIG. 19 (SEQ ID NO:
- 49), FIG. 22 (SEQ ID NO:
- 59), FIG. 24 (SEQ ID NO:
- 64), FIG. 26 (SEQ ID NO:
- 69), FIG. 28 (SEQ ID NO:
- 71), FIG. 30 (SEQ ID NO:
- 73), FIG. 32 (SEQ ID NO:
- 84), FIG. 34 (SEQ ID NO:
- 91), FIG. 36 (SEQ ID NO:
- 96), FIG. 38 (SEQ ID NO:
- 104), FIG. 40 (SEQ ID NO:
- 109), FIG. 42 (SEQ ID NO:
- 114), FIG. 44 (SEQ ID NO:
- 119), FIG. 46 (SEQ ID NO:
- 127), FIG. 48 (SEQ ID NO:
- 132), FIG. 50 (SEQ ID NO:
- 137), FIG. 52 (SEQ ID NO:
- 142), FIG. 54 (SEQ ID NO:
- 148), FIG. 56 (SEQ ID NO:
- 153), FIG. 58 (SEQ ID NO:
- 159), FIG. 60 (SEQ ID NO:
- 164), FIG. 62 (SEQ ID NO:
- 170), FIG. 64 (SEQ ID NO:
- 175), FIG. 66 (SEQ ID NO:
- 177), FIG. 68 (SEQ ID NO:
- 185), FIG. 70 (SEQ ID NO:
- 190), FIG. 72 (SEQ ID NO:
- 195), FIG. 74 (SEQ ID NO:
- 201), FIG. 76 (SEQ ID NO:
- 207), FIG. 78 (SEQ ID NO:
- 213), FIG. 80 (SEQ ID NO:
- 221), FIG. 82 (SEQ ID NO:
- 227), FIG. 84 (SEQ ID NO:
- 236), FIG. 86 (SEQ ID NO:
- 245), FIG. 88 (SEQ ID NO:
- 250), FIG. 90 (SEQ ID NO:
- 255), FIG. 92 (SEQ ID NO:
- 257), FIG. 94 (SEQ ID NO:
- 259), FIG. 96 (SEQ ID NO:
- 261), FIG. 98 (SEQ ID NO:
- 263), FIG. 100 (SEQ D NO:
- 285), FIG. 102 (SEQ ID NO:
- 290), FIG. 104 (SEQ ID NO:
- 292), FIG. 106 (SEQ ID NO:
- 294), FIG. 108 (SEQ ID NO:
- 310), FIG. 110 (SEQ ID NO:
- 315), FIG. 112 (SEQ ID NO:
- 320), FIG. 114 (SEQ ID NO:
- 325), FIG. 116 (SEQ ID NO:
- 332), FIG. 118 (SEQ ID NO:
- 339), FIG. 120 (SEQ ID NO:
- 341), FIG. 122 (SEQ ID NO:
- 377) and FIG. 124 (SEQ ID NO:
- 423).
Isolated PRO polypeptide having at least 80% sequence identity to the amino acid sequence encoded by the nucleotide deposited under accession number ATCC 209258, ATCC 209256, ATCC 209264, ATCC 209250, ATCC 209375, ATCC 209378, ATCC 209384, ATCC 209396, ATCC 209420, ATCC 209480, ATCC 209265, ATCC 209257, ATCC 209262, ATCC 209253, ATCC 209402, ATCC 209401, ATCC 209397, ATCC 209400, ATCC 209385, ATCC 209367, ATCC 209432, ATCC 209263, ATCC 209251, ATCC 209255, ATCC 209252, ATCC 209373, ATCC 209370, ATCC 209523, ATCC 209372, ATCC 209374, ATCC 209373, ATCC209382, ATCC 209383, ATCC 209403, ATCC 209398, ATCC.209399, ATCC 209392, ATCC 209387, ATCC209388, ATCC209394, ATCC 209421, ATCC 209393, ATCC209418, ATCC 209485, ATCC209483, ATCC 209482, ATCC 209491, ATCC 209481, ATCC 209438, ATCC 209927, ATCC 209439, ATCC 209489, ATCC 209433, ATCC 209488, ATCC 209434, ATCC 209395, ATCC 209486, ATCC 209490, ATCC 209484, ATCC 209371 or ATCC 203553.
Isolated nucleic acid having at least 80% nucleic acid sequence identity to:
- (a) a nucleotide sequence encoding the polypeptide shown in FIG. 2 (SEQ ID NO:
- 2), FIG. 4 (SEQ ID) NO:
- 4), FIG. 6 (SEQ ID NO:
- 12), FIG. 9 (SEQ ID NO:
- 18), FIG. 11 (SEQ ID NO:
- 23), FIG. 13 (SEQ ID NO:
- 28), FIG. 15 (SEQ ID NO:
- 34), FIG. 17 (SEQ ID NO:
- 39), FIG. 19 (SEQ ID NO:
- 49), FIG. 22 (SEQ ID NO:
- 59), FIG. 24 (SEQ ID NO:
- 64), FIG. 26 (SEQ ID NO:
- 69), FIG. 28 (SEQ ID NO:
- 71), FIG. 30 (SEQ ID NO:
- 73), FIG. 32 (SEQ ID NO:
- 84), FIG. 34 (SEQ ID NO:
- 91), FIG. 36 (SEQ ID NO:
- 96), FIG. 38 (SEQ ID NO:
- 104), FIG. 40 (SEQ ID NO:
- 109), FIG. 42 (SEQ ID NO:
- 114), FIG. 44 (SEQ ID NO:
- 119), FIG. 46 (SEQ ID NO:
- 127), FIG. 48 (SEQ ID NO:
- 132), FIG. 50 (SEQ ID NO:
- 137), FIG. 52 (SEQ ID NO:
- 142), FIG. 54 (SEQ ID NO:
- 148), FIG. 56 (SEQ ID NO:
- 153), FIG. 58 (SEQ ID NO:
- 159), FIG. 60 (SEQ ID NO:
- 164), FIG. 62 (SEQ ID NO:
- 170), FIG. 64 (SEQ ID NO:
- 175), FIG. 66 (SEQ ID NO:
- 177), FIG. 68 (SEQ ID NO:
- 185), FIG. 70 (SEQ ID NO:
- 190), FIG. 72 (SEQ ID NO:
- 195), FIG. 74 (SEQ ID NO:
- 201), FIG. 76 (SEQ ID NO:
- 207), FIG. 78 (SEQ ID NO:
- 213), FIG. 80 (SEQ ID NO:
- 221), FIG. 82 (SEQ ID NO:
- 227), FIG. 84 (SEQ ID NO:
- 236), FIG. 86 (SEQ ID NO:
- 245), FIG. 88 (SEQ ID NO:
- 250), FIG. 90 (SEQ ID NO:
- 255), FIG. 92 (SEQ ID NO:
- 257), FIG. 94 (SEQ ID NO:
- 259), FIG. 96 (SEQ ID NO:
- 261), FIG. 98 (SEQ ID NO:
- 263), FIG. 100 (SEQ ID NO:
- 285), FIG. 102 (SEQ ID NO:
- 290), FIG. 104 (SEQ ID NO:
- 292), FIG. 106 (SEQ ID NO:
- 294), FIG. 108 (SEQ ID NO:
- 310), FIG. 110 (SEQ ID NO:
- 315), FIG. 112 (SEQ ID NO:
- 320), FIG. 114 (SEQ ID NO:
- 325), FIG. 116 (SEQ ID NO:
- 332), FIG. 118 (SEQ ID NO:
- 339), FIG. 120 (SEQ ID NO:
- 341), FIG. 122 (SEQ ID NO:
- 377) or FIG. 124 (SEQ ID NO:
- 423), lacking its associated signal peptide;
- (b) a nucleotide sequence encoding an extracellular domain of the polypeptide shown in FIG. 2 (SEQ ID NO:
- 2), FIG. 4 (SEQ ID NO:
- 4), FIG. 6 (SEQ ID NO:
- 12), FIG. 9 (SEQ ID NO:
- 18), FIG. 11 (SEQ ID NO:
- 23), FIG. 13 (SEQ ID NO:
- 28), FIG. 15 (SEQ ID NO:
- 34), FIG. 17 (SEQ ID NO:
- 39), FIG. 19 (SEQ ID NO:
- 49), FIG. 22 (SEQ ID NO:
- 59), FIG. 24 (SEQ ID NO:
- 64), FIG. 26 (SEQ ID NO:
- 69), FIG. 28 (SEQ ID NO:
- 71), FIG. 30 (SEQ ID NO:
- 73), FIG. 32 (SEQ ID NO:
- 84), FIG. 34 (SEQ ID NO:
- 91), FIG. 36 (SEQ ID NO:
- 96), FIG. 38 (SEQ ID NO:
- 104), FIG. 40 (SEQ ID NO:
- 109), FIG. 42 (SEQ ID NO:
- 114), FIG. 44 (SEQ ID NO:
- 119), FIG. 46 (SEQ ID NO:
- 127), FIG. 48 (SEQ ID NO:
- 132), FIG. 50 (SEQ ID NO:
- 137), FIG. 52 (SEQ ID NO:
- 142), FIG. 54 (SEQ ID NO:
- 148), FIG. 56 (SEQ ID NO:
- 153), FIG. 58 (SEQ ID NO:
- 159), FIG. 60 (SEQ ID NO:
- 164), FIG. 62 (SEQ ID NO:
- 170), FIG. 64 (SEQ ID NO:
- 175), FIG. 66 (SEQ ID NO:
- 177), FIG. 68 (SEQ ID NO:
- 185), FIG. 70 (SEQ ID NO:
- 190), FIG. 72 (SEQ ID NO:
- 195), FIG. 74 (SEQ ID NO:
- 201), FIG. 76 (SEQ ID NO:
- 207), FIG. 78 (SEQ ID NO:
- 213), FIG. 80 (SEQ ID NO:
- 221), FIG. 82 (SEQ ID NO:
- 227), FIG. 84 (SEQ ID NO:
- 236), FIG. 86 (SEQ ID NO:
- 245), FIG. 88 (SEQ ID NO:
- 250), FIG. 90 (SEQ ID NO:
- 255), FIG. 92 (SEQ ID NO:
- 257), FIG. 94 (SEQ ID NO:
- 259), FIG. 96 (SEQ ID NO:
- 261), FIG. 98 (SEQ ID NO:
- 263), FIG. 100 (SEQ ID NO:
- 285), FIG. 102 (SEQ ID NO:
- 290), FIG. 104 (SEQ ID NO:
- 292), FIG. 106 (SEQ ID NO:
- 294), FIG. 108 (SEQ ID NO:
- 310), FIG. 110 (SEQ ID NO:
- 315), FIG. 112 (SEQ ID NO:
- 320), FIG. 114 (SEQ ID NO:
- 325), FIG. 116 (SEQ ID NO:
- 332), FIG. 118 (SEQ ID NO:
- 339), FIG. 120 (SEQ ID NO:
- 341), FIG. 122 (SEQ ID NO:
- 377) or FIG. 124 (SEQ ID NO:
- 423), with its associated signal peptide;
- or
- (c) a nucleotide sequence encoding an extracellular domain of the polypeptide shown in FIG. 2 (SEQ ID NO:
- 2), FIG. 4 (SEQ ID NO:
- 4), FIG. 6 (SEQ ID NO:
- 12), FIG. 9 (SEQ ID NO:
- 18), FIG. 11 (SEQ ID NO:
- 23), FIG. 13 (SEQ ID NO:
- 28), FIG. 15 (SEQ ED NO:
- 34), FIG. 17 (SEQ ID NO:
- 39), FIG. 19 (SEQ ID NO:
- 49), FIG. 22 (SEQ ID NO:
- 59), FIG. 24 (SEQ ID NO:
- 64), FIG. 26 (SEQ ID NO:
- 69), FIG. 28 (SEQ ID NO:
- 71), FIG. 30 (SEQ ID NO:
- 73), FIG. 32 (SEQ ID NO:
- 84), FIG. 34 (SEQ ID NO:
- 91), FIG. 36 (SEQ ID NO:
- 96), FIG. 38 (SEQ ID NO:
- 104), FIG. 40 (SEQ ID NO:
- 109), FIG. 42 (SEQ ID NO:
- 114), FIG. 44 (SEQ ID NO:
- 119), FIG. 46 (SEQ ID NO:
- 127), FIG. 48 (SEQ ID NO:
- 132), FIG. 50 (SEQ ID NO:
- 137), FIG. 52 (SEQ ID NO:
- 142), FIG. 54 (SEQ ID NO:
- 148), FIG. 56 (SEQ ID NO:
- 153), FIG. 58 (SEQ ID NO:
- 159), FIG. 60 (SEQ ID NO:
- 164), FIG. 62 (SEQ ID NO:
- 170), FIG. 64 (SEQ ID NO:
- 175), FIG. 66 (SEQ ID NO:
- 177), FIG. 68 (SEQ ID NO:
- 185), FIG. 70 (SEQ ID NO:
- 190), FIG. 72 (SEQ ID NO:
- 195), FIG. 74 (SEQ ID NO:
- 201), FIG. 76 (SEQ ID NO:
- 207), FIG. 78 (SEQ ID NO:
- 213), FIG. 80 (SEQ ID NO:
- 221), FIG. 82 (SEQ ID NO:
- 227), FIG. 84 (SEQ ID NO:
- 236), FIG. 86 (SEQ ID NO:
- 245), FIG. 88 (SEQ ID NO:
- 250), FIG. 90 (SEQ ID NO:
- 255), FIG. 92 (SEQ ID NO:
- 257), FIG. 94 (SEQ ID NO:
- 259), FIG. 96 (SEQ ID NO:
- 261), FIG. 98 (SEQ ID NO:
- 263), FIG. 100 (SEQ ID NO:
- 285), FIG. 102 (SEQ ID NO:
- 290), FIG. 104 (SEQ ID NO:
- 292), FIG. 106 (SEQ ID NO:
- 294), FIG. 108 (SEQ ID NO:
- 310), FIG. 110 (SEQ ID NO:
- 315), FIG. 112 (SEQ ID NO:
- 320), FIG. 114 (SEQ ID NO:
- 325), FIG. 116 (SEQ ID NO:
- 332), FIG. 118 (SEQ ID NO:
- 339), FIG. 120 (SEQ ID NO:
- 341), FIG. 122 (SEQ ID NO:
- 377) or FIG. 124 (SEQ ID NO:
- 423), lacking its associated signal peptide.
An isolated polypeptide having at least 80% amino acid sequence identity to:
- (a) the polypeptide shown in FIG. 2 (SEQ ID NO:
- 2), FIG. 4 (SEQ ID NO:
- 4), FIG. 6 (SEQ ID NO:
- 12), FIG. 9 (SEQ ID NO:
- 18), FIG. 11 (SEQ ID NO:
- 23), FIG. 13 (SEQ ID NO:
- 28), FIG. 15 (SEQ ID NO:
- 34), FIG. 17 (SEQ ID NO:
- 39), FIG. 19 (SEQ ID NO:
- 49), FIG. 22 (SEQ ID NO:
- 59), FIG. 24 (SEQ ID NO:
- 64), FIG. 26 (SEQ ID NO:
- 69), FIG. 28 (SEQ ID NO:
- 71), FIG. 30 (SEQ ID NO:
- 73), FIG. 32 (SEQ ID NO:
- 84), FIG. 34 (SEQ ID NO:
- 91), FIG. 36 (SEQ ID NO:
- 96), FIG. 38 (SEQ ID NO:
- 104), FIG. 40 (SEQ ID NO:
- 109), FIG. 42 (SEQ ID NO:
- 114), FIG. 44 (SEQ ID NO:
- 119), FIG. 46 (SEQ ID NO:
- 127), FIG. 48 (SEQ ID NO:
- 132), FIG. 50 (SEQ ID NO:
- 137), FIG. 52 (SEQ ID NO:
- 142), FIG. 54 (SEQ ID NO:
- 148), FIG. 56 (SEQ ID NO:
- 153), FIG. 58 (SEQ ID NO:
- 159), FIG. 60 (SEQ ID NO:
- 164), FIG. 62 (SEQ ID NO:
- 170), FIG. 64 (SEQ ID NO:
- 175), FIG. 66 (SEQ ID NO:
- 177), FIG. 68 (SEQ ID NO:
- 185), FIG. 70 (SEQ ID NO:
- 190), FIG. 72 (SEQ ID NO:
- 195), FIG. 74 (SEQ ID NO:
- 201), FIG. 76 (SEQ ID NO:
- 207), FIG. 78 (SEQ ID NO:
- 213), FIG. 80 (SEQ ID NO:
- 221), FIG. 82 (SEQ ID NO:
- 227), FIG. 84 (SEQ ID NO:
- 236), FIG. 86 (SEQ ID NO:
- 245), FIG. 88 (SEQ ID NO:
- 250), FIG. 90 (SEQ ID NO:
- 255), FIG. 92 (SEQ ID NO:
- 257), FIG. 94 (SEQ ID NO:
- 259), FIG. 96 (SEQ ID NO:
- 261), FIG. 98 (SEQ ID NO:
- 263), FIG. 100 (SEQ ID NO:
- 285), FIG. 102 (SEQ ID NO:
- 290), FIG. 104 (SEQ ID NO:
- 292), FIG. 106 (SEQ ID NO:
- 294), FIG. 108 (SEQ ID NO:
- 310), FIG. 110 (SEQ ID NO:
- 315), FIG. 112 (SEQ ID NO:
- 320), FIG. 114 (SEQ ID NO:
- 325), FIG. 116 (SEQ ID NO:
- 332), FIG. 118 (SEQ ID NO:
- 339), FIG. 120 (SEQ ID NO:
- 341), FIG. 122 (SEQ ID NO:
- 377) or FIG. 124. (SEQ ID NO:
- 423), lacking its associated signal peptide;
- (b) an extracellular domain of the polypeptide shown in FIG. 2 (SEQ ID NO:
- 2), FIG. 4 (SEQ ID NO:
- 4), FIG. 6 (SEQ ID NO:
- 12), FIG. 9 (SEQ ID NO:
- 18), FIG. 11 (SEQ ID NO:
- 23), FIG. 13 (SEQ ID NO:
- 28), FIG. 15 (SEQ ID NO:
- 34), FIG. 17 (SEQ ID NO:
- 39), FIG. 19 (SEQ ID NO:
- 49), FIG. 22 (SEQ ID NO:
- 59), FIG. 24 (SEQ ID NO:
- 64), FIG. 26 (SEQ ID NO:
- 69), FIG. 28 (SEQ ID NO:
- 71), FIG. 30 (SEQ ID NO:
- 73), FIG. 32 (SEQ ID NO:
- 84), FIG. 34 (SEQ ID NO:
- 91), FIG. 36 (SEQ ID NO:
- 96), FIG. 38 (SEQ ID NO:
- 104), FIG. 40 (SEQ ID NO:
- 109), FIG. 42 (SEQ ID NO:
- 114), FIG. 44 (SEQ ID NO:
- 119), FIG. 46 (SEQ ID NO:
- 127), FIG. 48 (SEQ ID NO:
- 132), FIG. 50 (SEQ ID NO:
- 137), FIG. 52 (SEQ ID NO:
- 142), FIG. 54 (SEQ ID NO:
- 148), FIG. 56 (SEQ ID NO:
- 153), FIG. 58 (SEQ ID NO:
- 159), FIG. 60 (SEQ ID NO:
- 164), FIG. 62 (SEQ ID NO:
- 170), FIG. 64 (SEQ ID NO:
- 175), FIG. 66 (SEQ ID NO:
- 177), FIG. 68 (SEQ ID NO:
- 185), FIG. 70 (SEQ ID NO:
- 190), FIG. 72 (SEQ ID NO:
- 195), FIG. 74 (SEQ ID NO:
- 201), FIG. 76 (SEQ ID NO:
- 207), FIG. 78 (SEQ ID NO:
- 213), FIG. 80 (SEQ ID NO:
- 221), FIG. 82 (SEQ ID NO:
- 227), FIG. 84 (SEQ ID NO:
- 236), FIG. 86 (SEQ ID NO:
- 245), FIG. 88 (SEQ ID NO:
- 250), FIG. 90 (SEQ ID NO:
- 255), FIG. 92 (SEQ ID NO:
- 257), FIG. 94 (SEQ ID NO:
- 259), FIG. 96 (SEQ ID NO:
- 261), FIG. 98 (SEQ ID NO:
- 263), FIG. 100 (SEQ ID NO:
- 285), FIG. 102 (SEQ ID NO:
- 290), FIG. 104 (SEQ ID NO:
- 292), FIG. 106 (SEQ ID NO:
- 294), FIG. 108 (SEQ ID NO:
- 310), FIG. 110 (SEQ ID NO:
- 315), FIG. 112 (SEQ ID NO:
- 320), FIG. 114 (SEQ ID NO:
- 325), FIG. 116 (SEQ ID NO:
- 332), FIG. 118 (SEQ ID NO:
- 339), FIG. 120 (SEQ ID NO:
- 341), FIG. 122 (SEQ ID NO:
- 377) or FIG. 124 (SEQ ID NO:
- 423), with its associated signal peptide;
- or
- (c) an extracellular domain of the polypeptide shown in FIG. 2 (SEQ ID NO:
- 2), FIG. 4 (SEQ ID NO:
- 4), FIG. 6 (SEQ ID NO:
- 12), FIG. 9 (SEQ ID NO:
- 18), FIG. 11 (SEQ ID NO:
- 23), FIG. 13 (SEQ ID NO:
- 28), FIG. 15 (SEQ ID NO:
- 34), FIG. 17 (SEQ ID NO:
- 39), FIG. 19 (SEQ ID NO:
- 49), FIG. 22 (SEQ ID NO:
- 59), FIG. 24 (SEQ ID NO:
- 64), FIG. 26 (SEQ ID NO:
- 69), FIG. 28 (SEQ ID NO:
- 71), FIG. 30 (SEQ ID NO:
- 73), FIG. 32 (SEQ ID NO:
- 84), FIG. 34 (SEQ ID NO:
- 91), FIG. 36 (SEQ ID NO:
- 96), FIG. 38 (SEQ ID NO:
- 104), FIG. 40 (SEQ ID NO:
- 109), FIG. 42 (SEQ ID NO:
- 114), FIG. 44 (SEQ ID NO:
- 119), FIG. 46 (SEQ ID NO:
- 127), FIG. 48 (SEQ ID NO:
- 132), FIG. 50 (SEQ ID NO:
- 137), FIG. 52 (SEQ ID NO:
- 142), FIG. 54 (SEQ ID NO:
- 148), FIG. 56 (SEQ ID NO:
- 153), FIG. 58 (SEQ ID NO:
- 159), FIG. 60 (SEQ ID NO:
- 164), FIG. 62 (SEQ ID NO:
- 170), FIG. 64 (SEQ ID NO:
- 175), FIG. 66 (SEQ ID NO:
- 177), FIG. 68 (SEQ ID NO:
- 185), FIG. 70 (SEQ ID NO:
- 190), FIG. 72 (SEQ ID NO:
- 195), FIG. 74 (SEQ ID NO:
- 201), FIG. 76 (SEQ ID NO:
- 207), FIG. 78 (SEQ ID NO:
- 213), FIG. 80 (SEQ ID NO:
- 221), FIG. 82 (SEQ ID NO:
- 227), FIG. 84 (SEQ ID NO:
- 236), FIG. 86 (SEQ ID NO:
- 245), FIG. 88 (SEQ ID NO:
- 250), FIG. 90 (SEQ ID NO:
- 255), FIG. 92 (SEQ ID NO:
- 257), FIG. 94 (SEQ ID NO:
- 259), FIG. 96 (SEQ ID NO:
- 261), FIG. 98 (SEQ ID NO:
- 263), FIG. 100 (SEQ ID NO:
- 285), FIG. 102 (SEQ ID NO:
- 290), FIG. 104 (SEQ ID NO:
- 292), FIG. 106 (SEQ ID NO:
- 294), FIG. 108 (SEQ ID NO:
- 310), FIG. 110 (SEQ ID NO:
- 315), FIG. 112 (SEQ ID NO:
- 320), FIG. 114 (SEQ ID NO:
- 325), FIG. 116 (SEQ ID NO:
- 332), FIG. 118 (SEQ ID NO:
- 339), FIG. 120 (SEQ ID NO:
- 341), FIG. 122 (SEQ ID NO:
- 377) or FIG. 124 (SEQ ID NO:
- 423), lacking its associated signal peptide.
A method of detecting a PRO245 polypeptide in a sample suspected of containing a PRO245 polypeptide, said method comprising contacting said sample with a PRO1868 polypeptide and determining the formation of a PRO245/PRO1868 polypeptide conjugate in said sample, wherein the formation of said conjugate is indicative of the presence of a PRO245 polypeptide in said sample.
A method of detecting a PRO1868 polypeptide in a sample suspected of containing a PRO1868 polypeptide, said method comprising contacting said sample with a PRO245 polypeptide and determining the formation of a PRO245/PRO1868 polypeptide conjugate in said sample, wherein the formation of said conjugate is indicative of the presence of a PRO1868 polypeptide in said sample.
A method of linking a bioactive molecule to a cell expressing a PRO245 polypeptide, said method comprising contacting said cell with a PRO1868 polypeptide that is bound to said bioactive molecule and allowing said PRO245 and PRO1868 polypeptides to bind to one another, thereby linking said bioactive molecules to said cell.
A method of linking a bioactive molecule to a cell expressing a PRO1868 polypeptide, said method comprising contacting said cell with a PRO245 polypeptide that is bound to said bioactive molecule and allowing said PRO245 and PRO1868 polypeptides to bind to one another, thereby linking said bioactive molecules to said cell.
A method of modulating at least one biological activity of a cell expressing a PRO245 polypeptide, said method comprising contacting said cell with a PRO1868 polypeptide or an anti-PRO245 antibody, whereby said PRO 1868 polypeptide or said anti-PRO245 antibody binds to said PRO245 polypeptide, thereby modulating at least one biological activity of said cell.
A method of modulating at least one biological activity of a cell expressing a PRO1868 polypeptide, said method comprising contacting said cell with a PRO245 polypeptide or an anti-PRO1868 antibody, whereby said PRO245 polypeptide or said anti-PRO1868 antibody binds to said PRO1868 polypeptide, thereby modulating at least one biological activity of said cell.
Dependencies are inferred from the claim text.