Compositions and methods for treatment and detection of multiple cancers
AssigneeThe Regents of the University of California
InventorLinda M. Liau
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Abstract
The invention provides a method for inhibiting proliferation of cancer cells, as well as methods for detecting and treating various cancers, including cancer of the brain, lung, breast, prostate and colon. The method comprises contacting a cancer cell with a molecule that disrupts the biological activity of a GDOX molecule. In one embodiment, the molecule is an antibody directed against a GDOX peptide. In other embodiments, the molecule is an antisense nucleotide directed against a GDOX nucleic acid molecule, or a vaccine comprising a GDOX peptide or a polynucleotide encoding a GDOX peptide. The invention additionally provides methods for detecting and treating cancer using GDOX-related molecules.
Claims31
An expression vector comprising a nucleic acid molecule that encodes a GDOX polypeptide having the amino acid sequence shown in SEQ ID NO:
- 2, operably linked to an expression control sequence.
An immunogenic GDOX polypeptide comprising the amino acid sequence shown in SEQ ID NO:
- 3 and/or SEQ ID NO:
- 4.
An antibody that specifically binds a GDOX polypeptide.
An oligonucleotide that specifically hybridizes to a nucleic acid molecule that encodes a GDOX protein.
A method for inhibiting proliferation of cancer cells comprising contacting a cancer cell with a molecule that disrupts the biological activity of a GDOX molecule, wherein the biological activity comprises specific binding of GDOX to a GDOX antibody or expression of a GDOX polynucleotide.
A method for treating cancer in a subject comprising administering to the subject a molecule that disrupts the biological activity of a GDOX molecule, wherein the biological activity comprises specific binding of GDOX to a GDOX antibody or expression of a GDOX polynucleotide.
A method for detecting cancer comprising contacting a tissue specimen with a detectable molecule that specifically binds a GDOX molecule and detecting binding of the detectable molecule, wherein binding of the detectable molecule is indicative of cancer.
A method for identifying a cancer that is sensitive to tamoxifen comprising contacting a cancer specimen with a detectable molecule that specifically binds a GDOX molecule and detecting binding of the detectable molecule, wherein binding of the detectable molecule is indicative of cancer that is sensitive to tamoxifen.
Dependencies are inferred from the claim text.