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US 2004/0005639 A1Published application
Glycerylaldehyde-3-phosphate dehyrogenase promoter inducing cell death
OwnerRyoichi Ishitaniinventor
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Abstract
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) promoter DNA which induces cell death, and a screening method for an apoptosis-suppressing agent using it. According to this invention, an apoptosis-suppressing agent can be screened by measuring the promoter activity of the GAPDH gene which discovers specifically the GAPDH protein which guides cell death in cell death process using the host cell in which the transformation was carried out by the vector incorporating the GAPDH promoter DNA.
Claims8
An isolated and purified rat glyceraldehyde-3-phosphate dehydrogenase (GAPDH) promoter DNA.
A screening method for apoptosis suppresser which comprises:
- 1) inserting rat GAPDH promoter into a vector,
- 2) transforming host cells with the vector,
- 3) adding a tested compound and
- 4) measuring survival ratio of the host cells.
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