Irradiation conversion of thermoplastic to thermoset polymers
OwnerAlan M. Zamoreinventor
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Abstract
Disclosed is a radiation-crosslinkable thermoplastic polymer composition, a process for the preparation thereof, an angioplasty balloon and a medical catheter made using such a composition. The composition contains a reactive monomer cross-linker facilitates cross-linking of the reaction product upon contact of the cross-linker-containing composition with energy from a radiation source.
Claims33
A radiation cross-linkable medical angioplasty balloon or radiation cross-linkable medical catheter made from a thermoplastic cross-linkable composition, said thermoplastic cross-linkable composition comprising:
- (a) a thermoplastic polymer which is the reaction product of an aromatic polyisocyanate and a polyahl;
- and
- (b) a monomer crosslinker selected from the group consisting of methacrylate monomer crosslinkers and acrylate monomer crosslinkers, for conversion of at least a portion of said thermoplastic polymer to convert said portion from a thermoplastic to a thermoset state upon irradiation of said composition with energy from a radiation source.
A radiation cross-linked medical angioplasty balloon or radiation cross-linked medical catheter made from a cross-linked composition, wherein said cross-linked composition is produced by irradiating a cross-linkable composition comprising:
- (a) a thermoplastic polymer which is the reaction product of an aromatic polyisocyanate and a polyahl;
- and
- (b) a monomer crosslinker selected from the group consisting of methacrylate monomer crosslinkers and acrylate monomer crosslinkers, meta-phenylene dimaleimide, and combinations thereof;
- said monomer crosslinker present in said composition in an amount sufficient to cross-link at least a portion of said thermoplastic polymer to convert said portion from a thermoplastic to a thermoset state upon irradiation of said composition with energy from a radiation source.
A radiation cross-linkable medical angioplasty balloon or radiation cross-linkable medical catheter made from a thermoplastic cross-linkable composition, said thermoplastic cross-linkable composition comprising:
- (a) a thermoplastic polymer selected from the group consisting of nylon, a copolyester copolymer of poly(1,4-butanediol terephthalate) and poly(alkylene ether terephthalate), a copoly(ether-ester-amide) polymer, and copolymers of polylaurinlactam and polytetrahydrofuran, and a reaction product of an aliphatic polyisocyanate and a polyahl;
- and
- (b) a monomer cross-linker comprising acrylate monomer crosslinkers, said monomer cross-linker present in said composition in an amount sufficient to provide cross-linking of at least a portion of said thermoplastic polymer to convert said portion from a thermoplastic to a thermoset state upon irradiation of said composition with energy from a radiation source.
A radiation cross-linked medical angioplasty balloon or radiation cross-linked medical catheter made from a cross-linked composition, wherein said cross-linked composition is produced by irradiating a crosslinkable composition comprising:
- (a) a thermoplastic polymer selected from the group consisting of nylon, a copolyester copolymer of poly(1,4-butanediol terephthalate) and poly(alkylene ether terephthalate), a copoly(ether-ester-amide) polymer, and copolymers of polylaurinlactam and polytetrahydrofuran, and a reaction product of an aliphatic polyisocyanate and a polyahl;
- and
- (b) a monomer cross-linker comprising acrylate monomer crosslinkers, said monomer cross-linker present in said composition in an amount sufficient to cross-link at least a portion of said thermoplastic polymer to convert said portion from a thermoplastic to a thermoset state upon irradiation of said composition with energy from a radiation source.
The radiation crosslinked composition made by irradiating the radiation crosslinkable composition comprising:
- (a) a thermoplastic copoly(ether-ester-amide) polymer and
- (b) a monomer cross-linker selected from the group consisting of triallylisocyanurate (“TAIC”) or triallylcyanurate (“TAC”) allylic monomers, and combinations thereof,
- with energy from a radiation source,
- wherein said radiation crosslinked composition is in the form of a device selected from the group consisting of surgical gloves, angioplasty balloons, birth control sheathes, heat shrinkable tubing, heat-shrinkable film, wire and cable jackets, orthodontic ligatures, seals, gaskets, o-rings, shoe soles, toner wiper blades, medical implant devices, and coated wires.
A device selected from the group consisting of surgical gloves, angioplasty balloons, birth control sheathes, heat shrinkable tubing, heat-shrinkable film, wire and cable jackets, orthodontic ligatures, seals, gaskets, o-rings, shoe soles, toner wiper blades, medical implant devices, and coated wires containing a radiation crosslinked composition made by irradiating the radiation crosslinkable composition comprising:
- (a) a thermoplastic copoly(ether-ester-amide) polymer and
- (b) a monomer cross-linker selected from the group consisting of triallylisocyanurate (“TAIC”) or triallylcyanurate (“TAC”) allylic monomers, and combinations thereof,
- with energy from a radiation source.
The radiation crosslinked composition made by irradiating a radiation crosslinkable composition comprising:
- (a) a thermoplastic aromatic polyurethane polymer and
- (b) a monomer acrylic or methacrylic cross-linker, and combinations thereof, with the proviso that the monomer acrylic or methacrylic cross-linker is other than trimethylolpropane triacrylate, trimethylolpropane trimethacrylate, and triacrylformal, with energy from a radiation source, wherein said radiation crosslinked composition is in the form of heat shrinkable tubing.
An article suitable for, sterilization by exposure to heat or, sterilization by exposure to radiation, surface modification by exposure to radiation or surface grafting by exposure to radiation, comprising a cross-linked composition, wherein said cross-linked composition is produced by irradiating a crosslinkable composition comprising:
- (a) a thermoplastic polymer selected from the group consisting of nylon, a copolyester copolymer of poly(1,4-butanediol terephthalate) and poly(alkylene ether terephthalate), a copoly(ether-ester-amide) polymer, and copolymers of polylaurinlactam and polytetrahydrofuran, and a reaction product of a polyisocyanate and a polyahl;
- and combinations thereof, and
- (b) a monomer cross-linker selected from the group consisting of allylic monomer crosslinkers, methacrylate monomer crosslinkers, acrylate monomer crosslinkers, and combinations thereof;
- said monomer cross-linker present in said composition in an amount sufficient to cross-link at least a portion of said thermoplastic polymer to convert said portion from a thermoplastic to a thermoset state upon irradiation of said composition with energy from a radiation source, wherein the amount of crosslinked composition is sufficient to increase the radiation tolerance or heat sterilization tolerance of the article over that of the article alone without the crosslinked composition.
An article suitable for, sterilization by exposure to heat or, sterilization by exposure to radiation, surface modification by exposure to radiation or surface grafting by exposure to radiation, comprising a cross-linkable composition, wherein said cross-linkable composition comprises:
- (a) a thermoplastic polymer selected from the group consisting of nylon, a copolyester copolymer of poly(1,4-butanediol terephthalate) and poly(alkylene ether terephthalate), a copoly(ether-ester-amide) polymer, and copolymers of polylaurinlactam and polytetrahydrofuran, and a reaction product of a polyisocyanate and a polyahl;
- and combinations thereof, and
- (b) a monomer cross-linker selected from the group consisting of allylic monomer crosslinkers, methacrylate monomer crosslinkers, acrylate monomer crosslinkers, and combinations thereof;
- said monomer cross-linker present in said composition in an amount sufficient to provide cross-linking of at least a portion of said thermoplastic polymer from a thermoplastic to a thermoset state upon irradiation of said composition with energy from a radiation source,
- wherein the amount of crosslinkable composistion is sufficient to increase the radiation sterilization tolerance of the article over that of the article alone without the crosslinkable composition.
An wholly or partially encapsulated device, wholly or partially encapsulated with a cross-linkable composition, wherein said cross-linked composition is
- produced by irradiating a crosslinkable composition comprising:
- (a) a thermoplastic polymer selected from the group consisting of nylon, a copolyester copolymer of poly(1,4-butanediol terephthalate) and poly(alkylene ether terephthalate), a copoly(ether-ester-amide) polymer, and copolymers of polylaurinlactam and polytetrahydrofuran, and a reaction product of a polyisocyanate and a polyahl;
- and combinations thereof, and
- (b) a monomer cross-linker selected from the group consisting of allylic monomer crosslinkers, methacrylate monomer crosslinkers, acrylate monomer crosslinkers, and combinations thereof;
- with the proviso that for the reaction product of a polyisocyanate and a polyahl the monomer acrylic or methacrylic cross-linker is other than trimethylolpropane triacrylate, trimethylolpropane trimethacrylate, and triacrylformal,
- said monomer cross-linker present in said composition in an amount sufficient to provide cross-linking of at least a portion of said thermoplastic polymer from a thermoplastic to a thermoset state upon irradiation of said composition with energy from a radiation source,
- and wherein the crosslinked encapsulation composition is expanded to a larger size than the device to be encapsulated, by a heating and forming process, and then cooled to retain the expanded size, said expanded crosslinked encapsulation composition possessing the characteristic of “memory” due to the crosslinked polymer comprising the crosslinked encapsulation composition,
- and wherein the medical device to be wholly or partially encapsulated is placed within the expanded shaped object with “memory”,
- and wherein heat is applied to cause the expanded crosslinked encapsulation composition with “memory” to contract and wholly or partially encapsulate the device within.
Dependencies are inferred from the claim text.