Agents that stimulate therapeutic angiogenesis and techniques and devices that enable their delivery

An apparatus comprising:

• a catheter body capable of traversing a mammalian blood vessel;
• a dilatable balloon assembly coupled to the catheter body comprising a balloon having a proximal wall;
• at least one needle body disposed within the catheter body and comprising a lumen having dimensions suitable for a needle to be advanced therethrough, the at least one needle body comprising an end coupled to the proximal wall of the balloon;
• an imaging body disposed within the catheter body and comprising a lumen having dimensions suitable for a portion of an imaging device to be advanced therethrough and adapted to be shared simultaneously or sequentially with a guidewire;
• and
• a portion of an imaging device disposed within the imaging body adapted to generate imaging signals of the blood vessel.