Preparation of chiral amino-nitriles
OwnerDavid Robert Allen, Crystal A. Achenbach-McCarthyinventors
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Abstract
A process and intermediates for producing 3-amino nitrites. The process involves resolving an enantiomeric mixture of chiral 3-amino nitrites in the presence of a chiral acid in a solvent system to produce a chiral 3-amino nitrile salt. The process may further comprise a recrystalizing step, wherein an enantiomerically enriched 3-amino nitrile salt is produced. The process may further comprise a salt exchanging step, wherein another acid is added to the chiral 3-amino nitrile salt or the enantiomerically enriched 3-amino nitrile salt to produce another 3-amino nitrile salt.
Claims36
A process for producing 3-amino nitrile compounds comprising the steps of:
- providing an enantiomeric mixture of chiral 3-amino nitrites;
- and
- resolving said enantiomeric mixture of chiral 3-amino nitrites in the presence of a chiral acid in a solvent system to produce a chiral 3-amino nitrile salt.
An (R)-3-aminopentanenitrile dibenzoyl-(L)-tartrate salt having the following general structure:
- 10
An (R)-3-aminopentanenitrile-dibenzoyl-(D)-tartrate salt having the following general structure:
- 11
A process for producing 3-amino nitrile compounds comprising the steps of:
- providing an (R)-3-aminopentanenitrile dibenzoyl-(L)-tartrate salt having the following general structure:
- 12
- ;
- and
- adding another acid thereto to form another (R)-3-aminopentanenitrile salt.
A process for producing 3-amino nitrile compounds comprising the steps of:
- providing an (R)-3-aminopentanenitrile dibenzoyl-(D)-tartrate salt having the following general structure:
- 15
- ;
- and
- adding another acid thereto to form another (R)-3-aminopentanenitrile salt.
Dependencies are inferred from the claim text.