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US 2004/0002601 A1Published application
Method for producing cephalosporins
AssigneeACS DOBFAR S.p.A.
InventorsMaurizio Zenoni, Giovanni Fogliato, Mauro Filippi
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Abstract
A method for producing cephalosporins 7-substituted with an amino-thiazolylacetic group by reacting 7-ACA or its derivatives having the amino group and the carboxyl protected with reactive derivatives of amino-thiazolylacetic acid.
Claims4
A method for producing cephalosporins 7-substituted with an amino-thiazolylacetic group of formula
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- in which R1 is hydrogen or a residue of a nucleophilic compound, R2 is a hydroxyl or substituted hydroxyl, R3 is hydrogen or methoxyl, wherein an acyl group of formula
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- is introduced into the amino group of a molecule of formula
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- by reacting in an anhydrous organic solvent a compound of formula (III) with a compound of formula
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- where R4 is a C1-C4 alkyl, finally removing the trimethylsilyl groups by known methods, to give the cephalosporins of formula (I).
5 more elements
Dependencies are inferred from the claim text.