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US 2004/0002595 A1Published application
Nucleic acid labeling compounds
AssigneeAffymetrix, Inc.
InventorsGlenn McGall, Anthony D. Barone
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Abstract
Nucleic acid labeling compounds containing heterocyclic derivatives are disclosed. The heterocyclic derivative containing compounds are synthesized by condensing a heterocyclic derivative with a cyclic group (e.g. a ribofuranose derivative). The labeling compounds are suitable for enzymatic attachment to a nucleic acid, either terminally or internally, to provide a mechanism of nucleic acid detection.
Claims15
A nucleic acid labeling compound of the following structure:
- 48
- wherein A is H or a functional group that permits the attachment of the nucleic acid labeling compound to a nucleic acid;
- X is O, S, NR1 or CHR2, wherein R1 and R2 are, independently, H, alkyl or aryl;
- Y is H, N3, F, OR9, SR9 or NHR9, wherein R9 is H, alkyl or aryl;
- Z is H, N3, F or OR10, wherein R10 is H, alkyl or aryl;
- L is amido alkyl;
- Q is a detectable moiety;
- and
- M is a connecting group, wherein m is an integer ranging from 0 to about 3.
6 more elements
Dependencies are inferred from the claim text.