US 2004/0002584 A1Published application

Proteins, polynucleotides encoding them and methods of using the same

AssigneeCuraGen Corporation

InventorsCarol E. A. Pena, Richard A. Shimkets, Li Li, Suresh G. Shenoy, Ramesh Kekuda, Kimberly A. Spytek, Corine A.M. Vernet, Uriel M. Malyankar, Xiaojia (Sasha) Guo, Vladimir Y. Gusev, Stacie J. Casman, Ferenc L. Boldog, Katarzyna Furtak, Velizar T. Tchernev, Meera Patturajan, Esha A. Gangolli, Muralidhara Padigaru, Xiaohong Liu, Jason C. Baumgartner, Valerie Gerlach, Steven K. Spaderna, Bryan D. Zerhusen

Life of this patent

Estimating the term…

patentgrep

Loading patent…

Abstract

Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

Claims41

Dependent claims

An isolated polypeptide comprising an amino acid sequence selected from the group consisting of:

(a) a mature form of an amino acid sequence selected from the group consisting of SEQ ID NOS:
2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, 56, 58, 60, 62, 64, 66, 68, 70, 72, 74, 76, 78, 80, 82, 84, 86, 88, 90, 92 and 94;
(b) a variant of a mature form of an amino acid sequence selected from the group consisting of SEQ ID NOS:
2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, 56, 58, 60, 62, 64, 66, 68, 70, 72, 74, 76, 78, 80, 82, 84, 86, 88, 90, 92 and 94, wherein one or more amino acid residues in said variant differs from the amino acid sequence of said mature form, provided that said variant differs in no more than 15% of the amino acid residues from the amino acid sequence of said mature form;
(c) an amino acid sequence selected from the group consisting of SEQ ID NOS:
2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, 56, 58, 60, 62, 64, 66, 68, 70, 72, 74, 76, 78, 80, 82, 84, 86, 88, 90, 92 and 94;
and
(d) a variant of an amino acid sequence selected from the group consisting of SEQ ID NOS:
2, 4,6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, 56, 58, 60, 62, 64, 66, 68, 70, 72, 74, 76, 78, 80, 82, 84, 86, 88, 90, 92 and 94 wherein one or more amino acid residues in said variant differs from the amino acid sequence of said mature form, provided that said variant differs in no more than 15% of amino acid residues from said amino acid sequence.

6 more elements

An isolated nucleic acid molecule comprising a nucleic acid sequence encoding a polypeptide comprising an amino acid sequence selected from the group consisting of:

(a) a mature form of an amino acid sequence selected from the group consisting of SEQ ID NOS:
2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, 56, 58, 60, 62, 64, 66, 68, 70, 72, 74, 76, 78, 80, 82, 84, 86, 88, 90, 92 and 94;
(b) a variant of a mature form of an amino acid sequence selected from the group consisting of SEQ ID NOS:
2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, 56, 58, 60, 62, 64, 66, 68, 70, 72, 74, 76, 78, 80, 82, 84, 86, 88, 90, 92 and 94, wherein one or more amino acid residues in said variant differs from the amino acid sequence of said mature form, provided that said variant differs in no more than 15% of the amino acid residues from the amino acid sequence of said mature form;
(c) an amino acid sequence selected from the group consisting of SEQ ID NOS:
2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, 56, 58, 60, 62, 64, 66, 68, 70, 72, 74, 76, 78, 80, 82, 84, 86, 88, 90, 92 and 94;
(d) a variant of an amino acid sequence selected from the group consisting of SEQ ID NOS:
2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, 56, 58, 60, 62, 64, 66, 68, 70, 72, 74, 76, 78, 80, 82, 84, 86, 88, 90, 92 and 94, wherein one or more amino acid residues in said variant differs from the amino acid sequence of said mature form, provided that said variant differs in no more than 15% of amino acid residues from said amino acid sequence;
(e) a nucleic acid fragment encoding at least a portion of a polypeptide comprising an amino acid sequence chosen from the group consisting of SEQ ID NOS:
2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, 56, 58, 60, 62, 64, 66, 68, 70, 72, 74, 76, 78, 80, 82, 84, 86, 88, 90, 92 and 94, or a variant of said polypeptide, wherein one or more amino acid residues in said variant differs from the amino acid sequence of said mature form, provided that said variant differs in no more than 15% of amino acid residues from said amino acid sequence;
and
(f) a nucleic acid molecule comprising the complement of (a), (b), (c), (d) or (e).

9 more elements

Dependencies are inferred from the claim text.

Facts

Application: 10/080,334Filed 21 Feb 2002
Priority: 21 Feb 2001
Published: 1 Jan 2004
Term ends: Not estimatedThe source records don’t support an estimate.

Classification8 codes

G05B 19/408
Numerical control [NC], i.e. automatically operating machines, in particular machine tools, e.g. in a manufacturing environment, so as to…
A61K 31/713
Compounds having three or more nucleosides or nucleotides: double-stranded nucleic acids or oligonucleotides
C07K 14/47
From vertebrates: from mammals
A61K 38/00
Medicinal preparations containing peptides

Family

Application60/270,523Us provisional application · filed 21 Feb 2001
Application60/270,220Us provisional application · filed 21 Feb 2001
Application60/270,797Us provisional application · filed 23 Feb 2001
Application60/270,810Us provisional application · filed 23 Feb 2001
Application60/274,295Us provisional application · filed 8 Mar 2001
Application60/276,677Us provisional application · filed 16 Mar 2001
Application60/276,400Us provisional application · filed 16 Mar 2001
Application60/278,796Us provisional application · filed 26 Mar 2001
Application60/281,521Us provisional application · filed 4 Apr 2001
Application60/286,548Us provisional application · filed 25 Apr 2001
Application60/291,765Us provisional application · filed 17 May 2001
Application60/311,595Us provisional application · filed 10 Aug 2001
Application60/311,980Us provisional application · filed 13 Aug 2001
Application60/318,526Us provisional application · filed 10 Sep 2001
Application60/322,712Us provisional application · filed 17 Sep 2001
Application60/330,307Us provisional application · filed 18 Oct 2001
US 7,108,972 B2Related patent
US 2004/0002584 A1This patent

From the US filing history. Foreign family members aren’t listed.