Crystallizable polylactone copolymers prepared from mono- and di-functional polymerization initiators
AssigneeEthicon, Inc.
InventorsHugh D. Newman JR., Sasa Andjelic, Brian M. Kelly, Dennis D. Jamiolkowski, Rao S. Bezwada
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Abstract
The present invention is directed to absorbable polylactone copolymers prepared in part from about 2 to about 80 mole percent glycolide, utilizing a combination of a monofunctional polymerization initiator and a di-functional polymerization initiator, to achieve rates of crystallization of the copolymer of at least about 2 times faster than the rate of crystallization of a copolymer made by a similar process utilizing either the mono-functional or the di-functional polymerization initiator alone. Medical devices containing such copolymers are also disclosed.
Claims14
An absorbable polylactone copolymer, comprising:
- from about 5 mole percent to about 10 mole percent of a first polymerized lactone comprising polymerized glycolide and about 95 mole percent to about 90 mole percent of a second polymerized lactone other than polymerized glycolide, wherein said copolymer has a degree of crystallinity of at least about 15%.
A medical device, comprising:
- an absorbable polylactone copolymer, said copolymer comprising from about 5 mole percent to about 10 mole percent of a first polymerized lactone comprising polymerized glycolide and about 95 mole percent to about 90 mole percent of a second polymerized lactone other than polymerized glycolide, wherein said copolymer has a degree of crystallinity of at least about 15%.
A composition for producing an absorbable polylactone copolymer comprising:
- a.) about 2 mole percent to about 80 mole percent a first lactone monomer comprising glycolide;
- b.) from about 98 to about 20 mole percent of a second lactone monomer other than glycolide;
- c.) a monofunctional initiator;
- and
- d.) a di-functional initiator;
- wherein the molar ratio of mono-functional to di-functional initiator is from about 10:90 to about 90:10;
An absorbable polylactone copolymer comprising from about 5 mole percent to about 10 mole percent of a first polylactone comprising polyglycolide and about 95 mole percent to about 90 mole percent of a second polylactone other than polyglycolide, wherein said copolymer has an average crystal size of about 25 microns or less.
Dependencies are inferred from the claim text.