Osteogenic paste compositions and uses thereof
AssigneeSDGI Holdings, Inc.
InventorWilliam F. McKay
Life of this patent
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Abstract
Described are osteogenic paste compositions with enhanced osteoinductive properties for use in bone repair. Compositions comprising a quickly resorbable paste carrier, a more slowly resorbed mineral matrix, and Bone Morphogenetic Protein (BMP) or other osteogenic factor are described which enable increased osteoinductive activity while retaining a reliable scaffold for the formation of new bone at the implant site. Methods for making and methods for therapeutic use of the compositions are also disclosed.
Claims29
An osteogenic paste composition effective for the induction of new bone growth in a primate, comprising:
- a resorbable paste carrier;
- an osteogenic factor;
- and
- a porous particulate mineral in an amount of at least 20% by volume of the composition, said amount being effective to provide a scaffold for bone ingrowth as the resorbable paste carrier is resorbed.
An osteogenic implant material effective for the induction of new bone growth in a mammal, comprising:
- a resorbable paste carrier comprising gelatin, the resorbable carrier formulated to be flowable at temperatures above the body temperature of the mammal, and to transition to a non-flowable mass at said body temperature;
- demineralized bone matrix;
- an osteogenic factor;
- and
- a particulate mineral having an average particle size of about 0.050 to about 5.0 mm, said mineral constituting at least 20% by volume of said composition.
A method for inducing bone growth in a primate, comprising:
- heating an effective amount of an osteogenic paste composition to a temperature at which it is flowable, said osteogenic implant material comprising a resorbable paste carrier that is flowable at temperatures above the body temperature of the primate, but which transitions to a non-flowable mass at or slightly above said body temperature;
- an osteogenic factor that stimulates osteoblasts and osteoclasts;
- and, a particulate mineral effective to provide a scaffold for bone ingrowth as the resorbable carrier is resorbed, said mineral constituting at least 20% by volume of the paste composition;
- implanting said osteogenic paste composition at a site of desired new bone formation;
- and
- cooling the osteogenic paste composition to a temperature sufficient to transition the osteogenic paste composition to a non-flowable mass.
Dependencies are inferred from the claim text.