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US 2004/0002541 A1Published application
Anti-spasticity of an eicosanoid analog
AssigneeVirginia Commonwealth University
InventorsBilly Martin, Raj K. Razdan, Anu Mahadevan, David Baker
Life of this patent
Estimating the term…
Abstract
The invention compounds and methods for the treatment of motor disorders. In particular, the invention provides eicosanoid analogs which are effective in ameliorating motor disorders such as spasticity caused by multiple sclerosis (MS).
Claims18
A compound having the structural formula
- 11
- wherein
- n ranges from 0 to 5, p ranges from 0 to 5, and n and p may be the same or different;
- X1=H, alkyl, Cl, Br, I, F, OH, OCH3, or O-alkyl;
- X2=H, alkyl, Cl, Br, I, F, OH, OCH3, or O-alkyl;
- Y1=H, alkyl, Cl, Br, I, F, OH, OCH3, or O-alkyl;
- Y2=H, alkyl Cl, Br, I, F, OH, OCH3, or O-alkyl;
- and X1, X2, Y1 and Y2 can be the same or different;
- and
- 12
- wherein
- m ranges from 1-7;
- R1=R2=H, or alkyl;
- and
- R3=OH, Cl, Br, I, CN, ONO, ONO2, NO2, H, or CH3.
12 more elements
A method of treating motor disorders in a patient in need thereof, comprising the step of
- administering to said patient a sufficient amount of a pure or salt form of a compound having the structural formula
- 13
- wherein
- n ranges from 0 to 5, p ranges from 0 to 5, and n and p may be the same or different;
- X1=H, alkyl, Cl, Br, I, F, OH, OCH3, or O-alkyl;
- X2=H, alkyl, Cl, Br, I, F, OH, OCH3, or O-alkyl;
- Y1=H, alkyl, Cl, Br, I, F, OH, OCH3, or O-alkyl;
- Y2=H, alkyl, Cl, Br, I, F, OH, OCH3, or O-alkyl;
- and X1, X2, Y1 and Y2 can be the same or different;
- and
- 14
- wherein
- m ranges from 1-7;
- R1=R2=H, or alkyl;
- and
- R3=OH, Cl, Br, I, CN, ONO, ONO2, NO2, H, or CH3.
13 more elements
A method for the treatment of spasticity in a patient in need thereof, comprising the step of
- administering to said patient a sufficient amount of a compound having the structural formula
- 15
- wherein
- n ranges from 0 to 5, p ranges from 0 to 5, and n and p may be the same or different;
- X1=H, alkyl, Cl, Br, I, F, OH, OCH3, or O-alkyl;
- X2=H, alkyl, Cl, Br, I, F, OH, OCH3, or O-alkyl;
- Y1=H, alkyl, Cl, Br, I, F, OH, OCH3, or O-alkyl;
- Y2=H, alkyl, Cl, Br, I, F, OH, OCH3, or O-alkyl;
- and X1, X2, Y1 and Y2 can be the same or different;
- and
- 16
- wherein
- m ranges from 1-7;
- R1=R2=H or alkyl;
- and
- R3=OH, Cl, Br, I, CN, ONO, ONO2, NO2, H, or CH3.
13 more elements
A composition comprising,
- 17
- wherein
- n ranges from 0 to 5, p ranges from 0 to 5, and n and p may be the same or different;
- X1=H, alkyl, Cl, Br, I, F, OH, OCH3, or O-alkyl;
- X2=H, alkyl, Cl, Br, I, F, OH, OCH3, or O-alkyl;
- Y1=H, alkyl, Cl, Br, I, F, OH, OCH3, or O-alkyl;
- Y2=H, alkyl, Cl, Br, I, F, OH, OCH3, or O-alkyl;
- and X1, X2, Y1 and Y2 can be the same or different;
- and
- 18
- wherein
- m ranges from 1-7;
- R1=R2=H or alkyl;
- and
- R3=OH, Cl, Br, I, CN, ONO, ONO2, NO2, H, or CH3;
- and a carrier, said compound being dissolved or dispersed in said carrier.
13 more elements
Dependencies are inferred from the claim text.