Methods of modulating c-kit tyrosine protein kinase function with indolinone compounds
AssigneeSugen, Inc.
InventorsKen Lipson, Gerald McMahon
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Abstract
The present invention concerns compounds and their use to inhibit the activity of a receptor tyrosine kinase. The invention is preferably used to treat cell proliferative disorders such as cancers characterized by over-activity or inappropriate activity c-kit kinase.
Claims10
A method for treating or preventing an abnormal condition in an organism, wherein said abnormal condition is associated with an aberration in a signal transduction pathway mediated by a c-kit kinase, wherein said method comprises the step of administering to said organism a therapeutically effective amount of an indolinone compound that modulates, in vitro, the catalytic activity of c-kit kinase.
Dependencies are inferred from the claim text.